NOTCH4
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Official Full Name
notch 4 -
Overview
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008] -
Synonyms
NOTCH4;notch 4;INT3;NOTCH3;neurogenic locus notch homolog protein 4;Notch homolog 4
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- C-His
- Insect Cell
- Mammalian Cell
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NOTCH4-120H | Recombinant Human NOTCH4 protein, His-tagged | E.coli | Human | His | Asp1715~Gly2001 | |
| Notch4-127R | Recombinant Rat Notch4 protein, His-tagged | E.coli | Rat | His | Thr1690~Leu1945 | |
| Notch4-1564M |
Recombinant Mouse Notch4 protein, His-tagged
|
C-His | Mouse | Glu1042-Leu1441 |
|
|
| NOTCH4-523H |
Recombinant Human NOTCH4 Protein (Met1-Phe637), His-tagged
|
Insect Cell | Human | His | Met1-Phe637 |
|
| NOTCH4-309H | Recombinant Human NOTCH4 | Mammalian Cell | Human | His |
|
|
| NOTCH4-3657H | Recombinant Human NOTCH4 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
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| NOTCH4-3657H-B | Recombinant Human NOTCH4 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
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| NOTCH4-4722H | Recombinant Human NOTCH4 Protein (Asp1715-Lys2002), N-His tagged | E.coli | Human | His | Asp1715-Lys2002 |
|
Involved Pathway
NOTCH4 involved in several pathways and played different roles in them. We selected most pathways NOTCH4 participated on our site, such as Dorso-ventral axis formation,Notch signaling pathway,Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOTCH4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | CTBP1,DTX3L,HER12,LFNG,RBPJA,APH1C,PTCRA,DLB,HER15.1,MAML1 |
| Thyroid hormone signaling pathway | RXRG,SLC16A10,ATP1B4,MED4,MED14,ATP1B2,ATP1A4,MAPK3,MED12,HDAC2 |
| Dorso-ventral axis formation | NOTCH1A,CPEB3,SPIRE2,GRB2,SPIRE1,CPEB2,ETV7,GRB2B,PIWIL1,SPIRE1A |
| MicroRNAs in cancer | MMP9,SHC4,RPS6KA5,RECK,HOXD10,NOTCH1,ZFPM2,IRS1,HRAS,DNMT1 |
Protein Function
NOTCH4 has several biochemical functions, for example, Notch binding,calcium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOTCH4 itself. We selected most functions NOTCH4 had, and list some proteins which have the same functions with NOTCH4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Notch binding | CHAC1,DLL1,JAG1A,DNER,HIF1AN,NCOR2,SNW1,JAG2,ADAM17,DLL4 |
| protein binding | ZNF2,EIF4A2,IL17RE,CCL28,ZSCAN10,CBY1,SOX10,XPO5,PPP1R16B,NOP56 |
| protein heterodimerization activity | BCL2A1,SMAD3,SOX4,SMAD4,HIST1H4K,RRAGA,SYCP3,INHBA,MAFGA,GABPA |
| receptor activity | AMFR,ITGB1B.1,F2RL1.2,STRA6,VAC14,GFRA2A,RNF139,CD7,NPY2R,ADCYAP1R1 |
| calcium ion binding | PCDHB5,SLC24A2,DSG1,UMOD,PCDHGA6,MICU2,SCIN,PCDHB13,S100A4,DSG1C |
Interacting Protein
NOTCH4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOTCH4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOTCH4.
Dlg4
NOTCH4 Related Signal Pathway
Resources
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References
- Lombardo, Y; Faronato, M; et al. Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells. BREAST CANCER RESEARCH 16:-(2014).
- Wu, WR; Shi, XD; et al. Clinicopathological significance of aberrant Notch receptors in intrahepatic cholangiocarcinoma. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7:3272-3279(2014).
