NNT
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Official Full Name
nicotinamide nucleotide transhydrogenase -
Overview
This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene. -
Synonyms
NNT;nicotinamide nucleotide transhydrogenase;NAD(P) transhydrogenase, mitochondrial;mitochondrial;MS701;NAD(P) transhydrogenase;NAD(P) transhydrogenase mitochondrial;NNTM;NNTM_HUMAN;Pyridine nucleotide transhydrogenase;OTTHUMP00000122432;OTTHUMP00000122433;OTTHUMP00000221608
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NNT-1321H | Recombinant Human NNT protein, GST-tagged | E.coli | Human | GST | 30-236 aa | |
| NNT-12777Z | Recombinant Zebrafish NNT | Mammalian Cells | Zebrafish | His |
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| NNT-3777HCL | Recombinant Human NNT 293 Cell Lysate | HEK293 | Human | Non |
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| NNT-3778HCL | Recombinant Human NNT 293 Cell Lysate | HEK293 | Human | Non |
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| NNT-5957H | Recombinant Human NNT Protein, GST-tagged | Wheat Germ | Human | GST |
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| NNT-6672HF | Recombinant Full Length Human NNT Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 207 amino acids |
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Involved Pathway
NNT involved in several pathways and played different roles in them. We selected most pathways NNT participated on our site, such as Nicotinate and nicotinamide metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NNT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GNSB,AOX3L1,SRM,POLE,HAL,ALDH7A1,COX11,ADH4,PLD1A,ackA |
| Nicotinate and nicotinamide metabolism | NT5C,NT5C1B-RDH14,NMRK2,NADSYN1,NMNAT3,NT5C1A,PNP,NNMT,NT5C2A,NT5C3L |
Protein Function
NNT has several biochemical functions, for example, NAD binding,NAD(P)+ transhydrogenase (AB-specific) activity,NAD(P)+ transhydrogenase (B-specific) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NNT itself. We selected most functions NNT had, and list some proteins which have the same functions with NNT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD binding | ADH1,GPD1C,ME2,TESCA,CTBP1,MDH1,GLYR1,GPD1A,HSD11B2,CYB5R3 |
| NAD(P)+ transhydrogenase activity | DHDH |
| NADP binding | FMO1,GAPDHS,G6PDX,HMGCRB,ME1,CRYZL1,HMGCRA,G6PD,H6PD,NOX1 |
Interacting Protein
NNT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NNT here. Most of them are supplied by our site. Hope this information will be useful for your research of NNT.
MVP;PAPD5;Wiz;Mkln1;MME;Junb;Papss1;HUWE1;ATL2;NEIL3;Cdc26;Mis12;SLAIN2
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