Nme8
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Official Full Name
NME/NM23 family member 8 -
Overview
This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6 -
Synonyms
TXNDC3;thioredoxin domain containing 3 (spermatozoa);thioredoxin domain-containing protein 3;CILD6;NME8;sperm specific thioredoxin 2;SPTRX2;CILD6;NM23 H8;NME8;Sperm specific thioredoxin 2;Spermatid specific thioredoxin 2;Sptrx 2;SPTRX2;Thioredoxin domain containing protein 3;sperm-specific thioredoxin 2;spermatid-specific thioredoxin-2;NM23-H8;sptrx-2;NME/NM23 family member 8
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Mammalian Cell
- HEK293
- HEK293T
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NME8-10745M | Recombinant Mouse NME8 Protein | Mammalian Cell | Mouse | His |
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| NME8-5581Z | Recombinant Zebrafish NME8 | Mammalian Cell | Zebrafish | His |
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| NME8-793H | Recombinant Human NME8 | Mammalian Cell | Human | His |
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| NME8-1164H | Recombinant Human NME8 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| NME8-3644H | Recombinant Human NME8 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| NME8-3644H-B | Recombinant Human NME8 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Nme8-4441M | Recombinant Mouse Nme8 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| NME8-5884H | Recombinant Human NME8 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| NME8-6113M | Recombinant Mouse NME8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NME8-6113M-B | Recombinant Mouse NME8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
Nme8 involved in several pathways and played different roles in them. We selected most pathways Nme8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Nme8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
Nme8 has several biochemical functions, for example, microtubule binding,nucleoside diphosphate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Nme8 itself. We selected most functions Nme8 had, and list some proteins which have the same functions with Nme8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleoside diphosphate kinase activity | CMPK2,NME5,AK5,NME4,NME3,AK8,NME9,NME1,NME2,AK1 |
| microtubule binding | KIF20B,CAMSAP1,MAP1LC3B,GOLSYN,KIF2A,CRIPT,MAP1B,S100A9,RAB11A,MACF1 |
Interacting Protein
Nme8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Nme8 here. Most of them are supplied by our site. Hope this information will be useful for your research of Nme8.
Resources
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References
- Karch, CM; Goate, AM; et al. Alzheimer's Disease Risk Genes and Mechanisms of Disease Pathogenesis. BIOLOGICAL PSYCHIATRY 77:43-51(2015).
- Liu, Y; Yu, JT; et al. Association between NME8 Locus Polymorphism and Cognitive Decline, Cerebrospinal Fluid and Neuroimaging Biomarkers in Alzheimer's Disease. PLOS ONE 9:-(2014).
