NLRP3
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Official Full Name
NLR family, pyrin domain containing 3 -
Overview
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5 UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5 UTR splice patterns are biologically valid. -
Synonyms
NLRP3;NLR family, pyrin domain containing 3;C1orf7, CIAS1, cold autoinflammatory syndrome 1;NACHT, LRR and PYD domains-containing protein 3;AGTAVPRL;AII;AVP;CLR1.1;Cryopyrin;FCAS;FCU;MWS;NALP3;nucleotide binding oligomerization domain;leuci
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Insect Cells
- His
- GST
- Non
- Flag
- DDK
- Myc
- Avi
- Fc
- SUMO
Involved Pathway
NLRP3 involved in several pathways and played different roles in them. We selected most pathways NLRP3 participated on our site, such as Immune System,Inflammasomes,Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NOD pathway | NLRP2,NLRP4,NLRP12,COPS6,NLRP10,NLRP7,AAMP,PRDM1,SUGT1 |
| Influenza A | PRSS1,MAP2K1,IL12A,IL12B,IFNAR1,IFNB1,TNFRSF10D,IL1A,HLA-DOB,PYCARD |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | PANX1,BTR16,TXNIPB,BTR18,PANX1B,BTR12,CYLD,BTR29,BTR30,BTR02 |
| Inflammasomes | SUGT1,TXNIP,PANX1,TXNIPA,BTR18,TXNIPB,BTR09,BTR02,BTR30,BTR16 |
| Innate Immune System | ABI1,CASP2,NLRP4E,S100B,POLR3C,DEFB106A,CYLD,PELI2,CRP,NCKAP1 |
| Immune System | CSHL1,CTSH,WASF2,CMTM2A,TRIM3,RAP1GAP2B,LRSAM1,ARIH1,ABI2,TIRAP |
| NOD-like receptor signaling pathway | IL8L1,IL-8,MAPK14B,HSP90AA1.2,CXCL1,MAPK12A,ERBB2IP,NFKBIB,SUGT1,TNFAIP3 |
| Pertussis | MAPK12,CALML3,CXCL6,FOS,TLR4,IL6,MAPK10,Casp3,IL12A,CFL2 |
Protein Function
NLRP3 has several biochemical functions, for example, ATP binding,peptidoglycan binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRP3 itself. We selected most functions NLRP3 had, and list some proteins which have the same functions with NLRP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | RUNX2B,RAD51L3,KDR,ATP1A1,DDX19B,PAN3,ABCG1,CAMK1GA,KITB,FICD |
| peptidoglycan binding | PGLYRP2,PGLYRP4,RNASE7,PGLYRP1,TREM2,PGLYRP3,TLR2,NOD1 |
| protein binding | USP54,PRUNE,SUSD2,ZNF488,RPS6KA1,DUSP15,ATG13,SIRPB1,ZBTB22,TMEM88 |
| transcription factor binding | CEBPA,ESR1,MAPK1,CSNK2B,BCL3,IFI203,INSIG2,PELP1,CDK9,HES7 |
| sequence-specific DNA binding | PBX1A,MNX2A,HSFY1,VDR,KLF5,HLX,ISX,FLI1A,NKX1.2LA,LHX9 |
Interacting Protein
NLRP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRP3.
PYCARD;MAVS;PHRF1;AP3B1;GEMIN2;UQCRQ;SMARCA5;URB1
Resources
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References
- Santoni, G; Cardinali, C; et al. Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons. JOURNAL OF NEUROINFLAMMATION 12:-(2015).
- Beshir, S; Shaheen, WA; et al. Serum Autoantibodies in Silicosis and Non-Silicosis Cement Workers. AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 58:238-244(2015).
