NLRP13
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Official Full Name
NLR family, pyrin domain containing 13 -
Overview
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs,;such as NALP13, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a;NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636),;also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD).;NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in;multiprotein complexes called inflammasomes (Tschopp et al., 2003 (PubMed 12563287)). -
Synonyms
NLRP13;NLR family, pyrin domain containing 13;NACHT, leucine rich repeat and PYD containing 13 , NALP13;NACHT, LRR and PYD domains-containing protein 13;CLR19.7;NOD14;nucleotide binding oligomerization domain;leucine rich repeat and pyrin domain containing 13;PAN13;LRR and PYD domains-containing protein 13;NACHT;NAL13_HUMAN;Nucleotide-binding oligomerization domain protein 14;NACHT, LRR and PYD containing protein 13;NACHT, leucine rich repeat and PYD containing 13;nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 13;NALP13
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NLRP13-5920H | Recombinant Human NLRP13 Protein, GST-tagged | Wheat Germ | Human | GST |
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| NLRP13-6753HF | Recombinant Full Length Human NLRP13 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 1043 amino acids |
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Involved Pathway
NLRP13 involved in several pathways and played different roles in them. We selected most pathways NLRP13 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRP13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
NLRP13 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by NLRP13 itself. We selected most functions NLRP13 had, and list some proteins which have the same functions with NLRP13. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
NLRP13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRP13 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRP13.
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References
- Glorioso, N; Herrera, VL; et al. Sex-Specific Effects of NLRP6/AVR and ADM Loci on Susceptibility to Essential Hypertension in a Sardinian Population. PLOS ONE 8:-(2013).
- Grigoryev, DN; Howell, MD; et al. Vaccinia virus-specific molecular signature in atopic dermatitis skin. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 125:153-159(2010).
