NLRP10
-
Official Full Name
NLR family, pyrin domain containing 10 -
Overview
Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. -
Synonyms
NLRP10;NLR family, pyrin domain containing 10;NACHT, leucine rich repeat and PYD containing 10 , NALP10;NACHT, LRR and PYD domains-containing protein 10;CLR11.1;NOD8;nucleotide binding oligomerization domain;leucine rich repeat and pyrin domain con
Recombinant Proteins
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cells
- His
- GST
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NLRP10-2866H | Recombinant Human NLRP10 protein, His-tagged | E.coli | Human | His | 1-180 aa | |
| NLRP10-3707H | Recombinant Human NLRP10 protein, GST-tagged | E.coli | Human | GST | 1-180 aa | |
| NLRP10-3803HCL | Recombinant Human NLRP10 293 Cell Lysate | HEK293 | Human | Non |
|
|
| NLRP10-1119HFL | Recombinant Full Length Human NLRP10 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
|
| NLRP10-1517H | Recombinant Human NLRP10 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| NLRP10-1517H-B | Recombinant Human NLRP10 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
||
| Nlrp10-4434M | Recombinant Mouse Nlrp10 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
|
|
| NLRP10-5638H | Recombinant Human NLRP10 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
|
Involved Pathway
NLRP10 involved in several pathways and played different roles in them. We selected most pathways NLRP10 participated on our site, such as NOD pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRP10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NOD pathway | NLRP2,SUGT1,AAMP,NLRP3,COPS6,NLRP4,PRDM1,NLRP12,NLRP7 |
Protein Function
NLRP10 has several biochemical functions, for example, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRP10 itself. We selected most functions NLRP10 had, and list some proteins which have the same functions with NLRP10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ZAP70,EPHA8,UBE2J1,FIGN,ATP1A1A.1,STK17A,COASY,MARK4,SCYL1,MTHFD1L |
Interacting Protein
NLRP10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRP10 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRP10.
Resources
Related Services
Related Products
References
- Krishnaswamy, JK; Singh, A; et al. Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3056-3061(2015).
- Glorioso, N; Herrera, VL; et al. Sex-Specific Effects of NLRP6/AVR and ADM Loci on Susceptibility to Essential Hypertension in a Sardinian Population. PLOS ONE 8:-(2013).
