NLRP1
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Official Full Name
NLR family, pyrin domain containing 1 -
Overview
NALP1 (DEFCAP/NAC/CARD7) is an NLR (Nod-like receptor) family member that has been implicated in the regulation of apoptosis and inflammatory responses. Structurally, NALP contains an amino-terminal PYRIN domain, followed by a nucleotide-binding site (NBS -
Synonyms
NLRP1;NLR family, pyrin domain containing 1;NACHT, leucine rich repeat and PYD (pyrin domain) containing 1 , NALP1;NACHT, LRR and PYD domains-containing protein 1;CARD7;CLR17.1;DEFCAP;DKFZp586O1822;KIAA0926;NAC;nucleotide binding oligomerization
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- HEK293
- Mammalian Cells
- His
- DDK&Myc
- Non
- Flag
- GST
- Avi&Fc&His
Involved Pathway
NLRP1 involved in several pathways and played different roles in them. We selected most pathways NLRP1 participated on our site, such as NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NOD-like receptor signaling pathway | IL-8,HSP90AB1,BIRC3,RELA,CARD18,MAPK3,MAPK14B,NFKBIAB,IL18,CASP5 |
Protein Function
NLRP1 has several biochemical functions, for example, ATP binding,cysteine-type endopeptidase activator activity involved in apoptotic process,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRP1 itself. We selected most functions NLRP1 had, and list some proteins which have the same functions with NLRP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SGK196,BMPR1BA,EPHB6,EPHA1,MTHFS,HCK,SYN2,ABCA13,CKBB,UBE2L3A |
| scaffold protein binding | NLGN4X,TREM2,NLGN3,GRIN2A,KRT8,LRP4,ADCY6,CASP8,IKBKB,MAPK3 |
| cysteine-type endopeptidase activator activity involved in apoptotic process | NOD1,GNB2L1,PYCARD,CTSH,RPS27L,NLRP12,MAPK9,BAD,BCL2L13,APAF1 |
| protein binding | ZNF524,RIMS1,PAWR,ADAM17,CAMK2A,CHMP4B,ATP7A,MET,SETDB2,ZUFSP |
| protein domain specific binding | NF2,E2F4,SHC4,VAPA,AIDA,HMGB2,CASKIN1,FOXA1,ZFP521,RQCD1 |
| enzyme binding | RYR2,CCND1,EGFR,TTN,CD40,PCCA,PEBP1,MLEC,ZNHIT6,CYP2A4 |
Interacting Protein
NLRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRP1.
BCL2;BCL2L1
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References
- Wang, T; Zhu, CL; et al. Role of NLRP3 and NLRP1 inflammasomes signaling pathways in pathogenesis of rheumatoid arthritis. ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE 7:827-831(2014).
- Marie, J; Kovacs, D; et al. Inflammasome activation and vitiligo/nonsegmental vitiligo progression. BRITISH JOURNAL OF DERMATOLOGY 170:816-823(2014).
