NLRC5
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Official Full Name
NLR family, CARD domain containing 5 -
Overview
This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. -
Synonyms
NLRC5;NLR family, CARD domain containing 5;protein NLRC5;CLR16.1;FLJ21709;NOD like receptor C5;NOD27;nucleotide binding oligomerization domain;leucine rich repeat and CARD domain containing 5;Caterpiller protein 16.1;FLJ39711;NLRC5_HUMAN;NOD-like receptor C5;NOD4;Nucleotide-binding oligomerization domain protein 27;Nucleotide-binding oligomerization domain protein 4;nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5;nucleotide-binding oligomerization domains 27;OTTHUMP00000164675;Protein Caterpiller 16.1
Recombinant Proteins
- Mouse
- Human
- Mammalian Cells
- HEK293
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NLRC5-10715M | Recombinant Mouse NLRC5 Protein | Mammalian Cells | Mouse | His |
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| NLRC5-1078H | Recombinant Human NLRC5 | Mammalian Cells | Human | His |
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| NLRC5-45HCL | Recombinant Human NLRC5 Over-expression cell lysate | HEK293 | Human | Myc&DDK |
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| NLRC5-489H | Recombinant Human NLRC5 protein, His-tagged | HEK293 | Human | His |
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| NLRC5-3640H | Recombinant Human NLRC5 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| NLRC5-3640H-B | Recombinant Human NLRC5 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| NLRC5-6094M | Recombinant Mouse NLRC5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NLRC5-6094M-B | Recombinant Mouse NLRC5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NLRC5 involved in several pathways and played different roles in them. We selected most pathways NLRC5 participated on our site, such as Immune System,Innate Immune System,Negative regulators of RIG-I/MDA5 signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | HERC5,TANK,PCBP2,TAX1BP1B,RNF135,RNF216,TAX1BP1 |
| Negative regulators of RIG-I/MDA5 signaling | CYLD,RNF135,TAX1BP1B,TAX1BP1,RNF216,HERC5,PCBP2 |
| Immune System | DEFB125,CYBB,XAF1,ATP6V1G3,SIRPB1,UNC93B1,KLRB1A,ASB14,MYO1C,OSBPL1A |
| Innate Immune System | PLD4,BTR12,TREM1,PANX1A,LY86,HBL3,SIGLEC15,CD180,DEFA6,TLR10 |
Protein Function
NLRC5 has several biochemical functions, for example, ATP binding,RNA polymerase II core promoter sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRC5 itself. We selected most functions NLRC5 had, and list some proteins which have the same functions with NLRC5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | LATS2,MYO7A,PRKACAA,KIF17,DHX34,PPP2R4,SMC2,PRPS1L1,EHD4,PIP4K2C |
| RNA polymerase II core promoter sequence-specific DNA binding | NFIL3,SP3,H3F3A,ZFP335,TBR1,SMAD1,FOS,STAT6,SOX11,SP1 |
| protein binding | MAGEB6,PFKM,CSDC2,SLC25A5,TRAF5,FAM9C,PLK3,FMR1,DUSP23,MCM8 |
Interacting Protein
NLRC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRC5.
Resources
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References
- Gultekin, Y; Eren, E; et al. Overexpressed NLRC3 Acts as an Anti-Inflammatory Cytosolic Protein. JOURNAL OF INNATE IMMUNITY 7:25-36(2015).
- Wybranska, I; Polus, A; et al. Apoptosis-related gene expression in glioblastoma (LN-18) and medulloblastoma (Daoy) cell lines. HUMAN CELL 26:137-148(2013).
