NLRC3
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Official Full Name
NLR family, CARD domain containing 3 -
Overview
This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] -
Synonyms
NLRC3;NLR family, CARD domain containing 3;NOD3;CLR16.2;protein NLRC3;CARD15-like protein;NOD-like receptor C3;caterpiller protein 16.2;nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NLRC3-1651H | Recombinant Human NLRC3 | Mammalian Cells | Human | His |
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| NLRC3-3638H | Recombinant Human NLRC3 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| NLRC3-3638H-B | Recombinant Human NLRC3 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| NLRC3-4075H | Recombinant Human NLRC3 Protein (Ser58-Val146), N-His tagged | E.coli | Human | His | Ser58-Val146 |
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Involved Pathway
NLRC3 involved in several pathways and played different roles in them. We selected most pathways NLRC3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
NLRC3 has several biochemical functions, for example, ATP binding,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRC3 itself. We selected most functions NLRC3 had, and list some proteins which have the same functions with NLRC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | SLAIN1,TAS2R117,MKS1,TMEM119B,ARPP19B,CCDC18,ZNF614,FANCE,VPS51,NDUFA6 |
| ATP binding | UBE2Q2,NEK1,EIF2AK1,MAPK11,SPATA5,UBE2D1A,RIPK3,NDUFA13,RFC2,GSG2 |
Interacting Protein
NLRC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRC3.
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References
- Mao, KR; Chen, SZ; et al. beta-arrestin1 Is Critical for the Full Activation of NLRP3 and NLRC4 Inflammasomes. JOURNAL OF IMMUNOLOGY 194:1867-1873(2015).
- Gultekin, Y; Eren, E; et al. Overexpressed NLRC3 Acts as an Anti-Inflammatory Cytosolic Protein. JOURNAL OF INNATE IMMUNITY 7:25-36(2015).
