NKX6-1
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Official Full Name
NK6 homeobox 1 -
Overview
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription;regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed;15056733).
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Avi
- Fc
Involved Pathway
NKX6-1 involved in several pathways and played different roles in them. We selected most pathways NKX6-1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX6-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | MAFA,ONECUT1,RFX6,INS2,MNX1,FOXA3,HNF4G,IAPP,BHLHA15,SLC2A2 |
Protein Function
NKX6-1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX6-1 itself. We selected most functions NKX6-1 had, and list some proteins which have the same functions with NKX6-1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | NR4A2,PRDM12,HIST1H4F,MKXA,PPARA,ADNP2,JUN,ESR2B,RBPJA,KLF14 |
| sequence-specific DNA binding | TRP63,HSFY1,EDF1,FEV,ENG2B,DLX4,LHX2,HIVEP2A,ASCL1A,WT1 |
| transcription factor activity, sequence-specific DNA binding | VAV1,TADA3,ZKSCAN1,ESR2,GRHL2A,NEUROD2,ATOH8,KLF10,RARGB,ZXDC |
| chromatin binding | SKIL,TP73,NCOA3,NFIA,CCDC111,LEF1,OST4,CAPNS2,GLI1,NR5A1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | FOSL1A,BCL11A,ELF4,ISL1,JDP2,JUN,ARID3B,PAX5,NKX2-8,MYPOP |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | SP3,IFI203,NKX3-2,RELA,ETS2,NR2C1,HELT,PPARA,NFIL3-6,CC2D1B |
Interacting Protein
NKX6-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX6-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX6-1.
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References
- Hald, J; Galbo, T; et al. Pancreatic islet and progenitor cell surface markers with cell sorting potential. DIABETOLOGIA 55:154-165(2012).
- Conrad, R; Jablonka, S; et al. Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).
