NKX6-1
-
Official Full Name
NK6 homeobox 1 -
Overview
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription;regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed;15056733).
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His&GST
- His
- N-GST,C-His
- His&Fc&Avi
- GST
Involved Pathway
NKX6-1 involved in several pathways and played different roles in them. We selected most pathways NKX6-1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX6-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | PKLR,HNF4G,NR5A2,SLC2A2,FOXA3,HNF4A,NKX6,HNF1A,MAFA,IAPP |
Protein Function
NKX6-1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX6-1 itself. We selected most functions NKX6-1 had, and list some proteins which have the same functions with NKX6-1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | POUV,NKX2.4B,NR2F1A,SPIC,PRRX1,POU5F3,CTCF,IRX7,HOXA7,PAX6A |
| DNA binding | MYPOP,RNF141,NUCB1,PA2G4,VDRB,ZNF34,TP63,ZFP28,NKX3.3,HIST1H2BF |
| transcription factor activity, sequence-specific DNA binding | CSRNP3,HMGA1A,CBFA2T2,BCL3,EGR3,ETV5B,SUPT4H1,LEF1,NR2F5,GCM1 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | REST,ZFPM2A,PPARA,ZFP746,IFI203,NFIL3-4,MLXIPL,BTG2,ZFP90,YY1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | TXK,FOSL2,FOSB,MYOG,ATF7,SMAD1,ZFP536,GMEB2,MXD1,TBP |
| chromatin binding | CUX1,HDAC7,NCOA3,MEF2A,SFPQ,FOSL2,NR5A2,CITED2,MBD5,ING5 |
Interacting Protein
NKX6-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX6-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX6-1.
Resources
Related Services
Related Products
References
- Hald, J; Galbo, T; et al. Pancreatic islet and progenitor cell surface markers with cell sorting potential. DIABETOLOGIA 55:154-165(2012).
- Conrad, R; Jablonka, S; et al. Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).
