NKD2
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Official Full Name
naked cuticle homolog 2 (Drosophila) -
Overview
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway. -
Synonyms
NKD2;naked cuticle homolog 2 (Drosophila);protein naked cuticle homolog 2;Dvl binding protein NKD2;naked cuticle 2;Naked2;hNkd2;Naked 2;naked-2;naked cuticle-2;OTTHUMP00000115406;OTTHUMP00000220490;Dvl-binding protein NKD2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NKD2-445H | Recombinant Human NKD2 Protein, His-tagged | E.coli | Human | His |
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| NKD2-1198HCL | Recombinant Human NKD2 cell lysate | Human | Non |
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| NKD2-5888H | Recombinant Human NKD2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| NKD2-6662HF | Recombinant Full Length Human NKD2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 311 amino acids |
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Involved Pathway
NKD2 involved in several pathways and played different roles in them. We selected most pathways NKD2 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | SIAH1,EP300,BTRC,NKD2B,MMP7,LEF1,FRAT2,WNT9B,MAPK8B,FZD7 |
Protein Function
NKD2 has several biochemical functions, for example, calcium ion binding,growth factor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKD2 itself. We selected most functions NKD2 had, and list some proteins which have the same functions with NKD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CDC26,PAXIP1,C22orf39,FAM158A,SMARCD3,RYR1,RCN2,PDIA3,TH1L,EXOSC4 |
| calcium ion binding | PCDH1G2,CAPS,TLL1,THBS4,MEGF6,CPNE6,PADI1,PRRG3,PCDHA9,EHD4 |
| growth factor binding | SDCBP,HTRA1A,REG3B,GHR,LTBP2,LTBP4,A2M,HTRA1B,ERBB3,IGFBP2B |
| ubiquitin protein ligase binding | HSPD1,PRKAR1A,PML,ERLIN2,DLG3,MOAP1,FZD6,WASH,CASP10,SLC22A18 |
Interacting Protein
NKD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKD2.
RCHY1;DVL1;TGFA;VDR;FUS;CDKN1A;GRB2;gltD1;ANAPC11;WWOX
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