NKAP
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Official Full Name
NFKB activating protein -
Overview
This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. -
Synonyms
NKAP;NFKB activating protein;NF-kappa-B-activating protein;FLJ22626;NF kappaB activating protein;NF-kappaB activating protein
Recombinant Proteins
- Chicken
- Rhesus macaque
- Rat
- Human
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
NKAP involved in several pathways and played different roles in them. We selected most pathways NKAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NKAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
NKAP has several biochemical functions, for example, chromatin DNA binding,chromatin binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKAP itself. We selected most functions NKAP had, and list some proteins which have the same functions with NKAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | ELAC2,MRPS14,CANX,IPO5,DDX52,SSBP1,RPL11,GTL3,FARSA,XRCC6 |
| chromatin DNA binding | H2AFZ,NOTCH1,MYOG,THRB,ATOH1,SLAMF7,GRHL2,INSM1B,H1F0,PPARGC1A |
| protein binding | SERPINB1A,ATXN2,ARNTL1B,PAGE5,DNAAF2,APOBEC2B,CNOT4,UBE2U,SHC4,PYDC1 |
| chromatin binding | BRD3,SMARCE1,ADNP,LRWD1,SMAD6,URI1,RFX4,TWIST2,NSD1,FOS |
Interacting Protein
NKAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKAP here. Most of them are supplied by our site. Hope this information will be useful for your research of NKAP.
PRPF3;PRPF40A;U2AF1;DHX8;DDX41;RBMX2;tax;SRPK1;RNPS1;Ddx41;DHX15;BUB3;NOS1AP
NKAP Related Signal Pathway
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