NHEJ1
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Official Full Name
nonhomologous end-joining factor 1 -
Overview
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008] -
Synonyms
NHEJ1;nonhomologous end-joining factor 1;XLF;non-homologous end-joining factor 1;XRCC4-like factor;protein cernunnos
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NHEJ1 involved in several pathways and played different roles in them. We selected most pathways NHEJ1 participated on our site, such as Non-homologous end-joining, which may be useful for your reference. Also, other proteins which involved in the same pathway with NHEJ1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-homologous end-joining | POLM,DNTT,DCLRE1C,PRKDC,XRCC6,POLL,FEN1,MRE11A,XRCC4,XRCC5 |
Protein Function
NHEJ1 has several biochemical functions, for example, DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NHEJ1 itself. We selected most functions NHEJ1 had, and list some proteins which have the same functions with NHEJ1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | AF251705,FASLG,PROC,MC1R,CENPH,IL15RA,NABP1,GGNBP2,ILKAP,AKR1C1 |
| DNA binding | FOXO1A,ZNF577,HDGF,TBX24,HBP1,UNCX4.1,PRDM10,ZNF620,TERFA,MYSM1 |
Interacting Protein
NHEJ1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NHEJ1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NHEJ1.
XRCC4;LIG4;XRCC5;H2AFX
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