NFATC4
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Official Full Name
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 -
Overview
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] -
Synonyms
NFATC4;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4;NFAT3;NF-AT3;NF-ATC4;nuclear factor of activated T-cells, cytoplasmic 4;T-cell transcription factor NFAT3
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NFATC4-1275H | Recombinant Human NFATC4, GST-tagged | E.coli | Human | GST | 228-582aa | |
| NFATC4-10613M | Recombinant Mouse NFATC4 Protein | Mammalian Cells | Mouse | His |
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| NFATC4-1188HCL | Recombinant Human NFATC4 cell lysate | Human | Non |
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| Nfatc4-4390M | Recombinant Mouse Nfatc4 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| NFATC4-6031M | Recombinant Mouse NFATC4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NFATC4-6031M-B | Recombinant Mouse NFATC4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| NFATC4-750H | Recombinant Human NFATC4 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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Involved Pathway
NFATC4 involved in several pathways and played different roles in them. We selected most pathways NFATC4 participated on our site, such as cGMP-PKG signaling pathway,Wnt signaling pathway,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | MEF2D,CALM1,NOS3,CREB3L1,PPP3CB,GTF2I,MYLK3,ATP1B1,MAPK3,CALML5 |
| Oxytocin signaling pathway | NRAS,CACNG4,GNAI1,ACTG1,Adcy4,GNAQ,PIK3CA,PPP1CC,CACNB1,CAMK2B |
| Wnt signaling pathway | AXIN1,FBXW2,PPARDB,WNT10B,LRP5,CAMK2B1,FZD7,WNT3,BAMBI,FZD5 |
| HTLV-I infection | MAP3K1,ANAPC5,POLD4,RELA,DVL3,Il2,PDGFRA,POLE2,SLC2A1,PPP3R1 |
| Hepatitis B | OSTN,IFNA13,TICAM2,NFATC2,PIK3CB,IFNA14,DDB2,EGR2,CCNE2,CASP10 |
| Axon guidance | AP2B1,GPC1A,EFNA2,PAK7,L1CAM,RASGRP4,COL9A1,ACTR2B,DLG3,CFL2 |
Protein Function
NFATC4 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,peroxisome proliferator activated receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC4 itself. We selected most functions NFATC4 had, and list some proteins which have the same functions with NFATC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | NFIL3-6,MZF1,TCF21,OVOL1,ZNF148,NFIL3,NKX6-2,ZGPAT,BCL11A,BHLHE40 |
| transcription factor binding | ADD1,HMGB1,PIK3R1,DRAP1,JUNBA,PARK7,PSMD4,HDAC1,GATA2,NLK |
| protein binding | RASGRP3,ZNF346,PRL2C2,ZNHIT1,PPP4R1,H3F3A,CENPI,ATXN7L3,EEF1D,TXN |
| peroxisome proliferator activated receptor binding | EP300,ASXL2,ASXL1,HMGA1,MED1,PPARGC1A,IKBKG,NR0B2,CREBBP,PRMT2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | RFX6,TXK,HNRNPC,SMAD4,EGR2,MED8,FOSL1A,NFE2L3,TFE3,ZNF114 |
| transcription coactivator activity | EP300,TCERG1,CITED1,SUB1,MAML2,KLF7,BCL10,NR5A1,HINFP,SMARCD1 |
Interacting Protein
NFATC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC4.
UBC;Dlg4;PASK;MAPK14;NR1I2;JUP;CCNG1;GPR22;ANKRD28;YWHAQ
NFATC4 Related Signal Pathway
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References
- Petra, H; Eva, H; et al. Molecular Profiling of Acute and Chronic Rejections of Renal Allografts. CLINICAL & DEVELOPMENTAL IMMUNOLOGY :-(2013).
- Minematsu, H; Shin, MJ; et al. Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages. CELLULAR SIGNALLING 23:1785-1793(2011).
