NFAM1
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Official Full Name
NFAT activating protein with ITAM motif 1 -
Overview
The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. -
Synonyms
NFAM1;NFAT activating protein with ITAM motif 1;NFAT activation molecule 1;CNAIP;NFAT activation molecule 1 precursor;Calcinerin/NFAT activating ITAM containing protein;NFAT-activating protein with ITAM motif 1;calcinerin/NFAT-activating ITAM-containing protein;calcineurin/NFAT-activating ITAM-containing protein;bK126B4.4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NFAM1-1272H | Recombinant Human NFAM1, GST-tagged | E.coli | Human | GST | 1-270aa | |
| NFAM1-3860HCL | Recombinant Human NFAM1 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
NFAM1 involved in several pathways and played different roles in them. We selected most pathways NFAM1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NFAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
NFAM1 has several biochemical functions, for example, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NFAM1 itself. We selected most functions NFAM1 had, and list some proteins which have the same functions with NFAM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | CD300C,AGER,CLDN3,ADCYAP1R1A,SEMA4D,LGR6,LYVE1,LAG3,FZD3A,CD79A |
Interacting Protein
NFAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFAM1.
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References
- Zawawi, MSF; Dharmapatni, AASSK; et al. Regulation of ITAM adaptor molecules and their receptors by inhibition of calcineurin-NFAT signalling during late stage osteoclast differentiation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 427:404-409(2012).
- Mori, J; Pearce, AC; et al. G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2. JOURNAL OF BIOLOGICAL CHEMISTRY 283:35419-35427(2008).
