NEU4
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Official Full Name
sialidase 4 -
Overview
The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. -
Synonyms
NEU4;sialidase 4;sialidase-4;neuraminidase 4;N-acetyl-alpha-neuraminidase 4;FLJ35928;MGC18222;MGC102757
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Mus musculus
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- GST
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NEU4 involved in several pathways and played different roles in them. We selected most pathways NEU4 participated on our site, such as Asparagine N-linked glycosylation,Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein,Glycosphingolipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEU4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | SULT4A1,AADAC,UCP2,ACER1,PPM1LB,CYP27A1,ELA2L,HPSE,FIG4,MED10 |
| Glycosphingolipid metabolism | NEU3,SUMF2,ARSH,GLTP,ARSK,GLTPA,CPTP,ARSJ,ARSD,ARSF |
| Post-translational protein modification | CBX8,TMED2,ALG2,B3GALTL,ARSI,GNE,TFG,UBA2,DAD1,ADAMTS8 |
| Metabolism of proteins | C19orf10,ADAMTS13,PROZ,SLC30A8,HDGF,SLC25A13,DNAJC24,SEC22A,GPR119,YKT6 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ALG2,ST6GALNAC1.2,DPAGT1,GNE,ST6GALNAC2,ST8SIA3,ST3GAL3A,ALG10B,MPDU1B,ST6GAL2B |
| Other glycan degradation | ENGASE,FUCA1.2,HEXB,GLB1,MANBA,MAN2C1,NEU3.4,NEU3.2,HEXDC,FUCA1 |
| Metabolism of lipids and lipoproteins | TIAM2,PMVK,ARF3,FABP11B,DHCR24,ALOX5AP,SPTLC1,FABP12,APOEA,PPM1LA |
| Asparagine N-linked glycosylation | MGAT4A,NAPG,GOLGA2,TRAPPC2,ST8SIA3,TRAPPC3,DERL2,SEC24A,ANKRD28,CTSC |
Protein Function
NEU4 has several biochemical functions, for example, exo-alpha-(2->3)-sialidase activity,exo-alpha-(2->6)-sialidase activity,exo-alpha-(2->8)-sialidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEU4 itself. We selected most functions NEU4 had, and list some proteins which have the same functions with NEU4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| exo-alpha-(2->6)-sialidase activity | NEU2,NEU3,NEU1 |
| exo-alpha-(2->3)-sialidase activity | NEU1,NEU3,NEU2 |
| protein binding | FLCN,AQP5,UCHL3,CRNKL1,ASAP2,OTUB2,EPB42,SNRNP25,CREBBP,MTIF3 |
| exo-alpha-sialidase activity | NEU3.1,NEU3.5,ST3GAL5L,NEU3.4,NEU3.2,NEU3.3,NEU3,NEU1 |
| exo-alpha-(2->8)-sialidase activity | NEU3,NEU1,NEU2 |
Interacting Protein
NEU4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEU4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEU4.
MDFI;RHOXF2;PLSCR1;Dlg4;RBPMS
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References
- Alghamdi, F; Guo, M; et al. A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes. CELLULAR SIGNALLING 26:1355-1368(2014).
- Itokazu, Y; Yu, RK; et al. Amyloid beta-Peptide 1-42 Modulates the Proliferation of Mouse Neural Stem Cells: Upregulation of Fucosyltransferase IX and Notch Signaling. MOLECULAR NEUROBIOLOGY 50:186-196(2014).
