NETO2
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Official Full Name
neuropilin (NRP) and tolloid (TLL)-like 2 -
Overview
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
NETO2;neuropilin (NRP) and tolloid (TLL)-like 2;neuropilin and tolloid-like protein 2;FLJ10430;NEOT2;BTCL2;FLJ14724;FLJ90456;Brain specific transmembrane protein;Brain specific transmembrane protein containing 2 CUB and 1 LDL receptor class A domains protein 2;Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2;NETO 2;NETO2_HUMAN;Neuropilin (NRP) and tolloid (TLL) like 2;Neuropilin and tolloid like protein 2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
NETO2 involved in several pathways and played different roles in them. We selected most pathways NETO2 participated on our site, such as ARMS-mediated activation,Activation of NMDA receptor upon glutamate binding and postsynaptic events,Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with NETO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of NMDA receptor upon glutamate binding and postsynaptic events | ADCY8,CAMKK1B,DLG4,NEFLB,CREB1B,ADCY1,PDPK1A,CREB1,ADCY3,SLC14A2 |
| Axon guidance | EZRA,COL9A3,EFNA2A,SPRED3,EPHB2,PEA15A,CDK5R1B,ROBO2,SLIT3,JAK1 |
| ARMS-mediated activation | PSME3,CNKSR1,FRS2A,FGFR1B,SPRED1,HBEGF,DUSP2,FGF10B,EGF,DUSP7 |
| BCR signaling pathway | IBTK,MAP4K1,CSK,POU2F2,MALT1,PAG1,DOK1,CSNK2A1 |
| Aldosterone synthesis and secretion | PRKCA,SLC14A2,NR4A2,CACNA1G,NPR1,PDE2A,ATF4,PLCB3,CREB3L4,AKR1C1 |
| Adrenergic signaling in cardiomyocytes | AGTR1A,FXYD2,CREB5,MAPK12,ATP1B3A,CACNA1D,PPP1R1A,PPP1CAA,PPP2R5B,CACNB2A |
| CREB phosphorylation through the activation of CaMKII | AKAP9,SLC14A2,DLG4,CREB1B,NEFLB |
Protein Function
NETO2 has several biochemical functions, for example, ATP binding,calcium-dependent protein serine/threonine phosphatase activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NETO2 itself. We selected most functions NETO2 had, and list some proteins which have the same functions with NETO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | SMAD4,YARS2,PLDN,DMRTC2,CAMK2G,SOD1,UPK1A,EPHX2,PDXK,ABCB10 |
| protein binding | MAGEA1,ARAP1,TRAPPC10,AGBL4,TFF1,MAGI1,OSBPL1A,FBN2,FOXD3,POU2F1 |
| calcium-dependent protein serine/threonine phosphatase activity | PPP3CB,PPP3R1,CAMK2G |
| calmodulin binding | SLC14A2,TRPC2,MKNK2A,MAP6,PDE1A,RYR1,MYH10,MKNK1,GAP43,ADCY1 |
| calmodulin-dependent protein kinase activity | CAMK1D,CAMK2D1,CAMK4,CAMK2G,MAPKAPK2,PNCK,CAMK2A,SLC14A2,MYLK2,CAMK1GA |
| ATP binding | GRK6,CSNK2A2,MSH3,ABCB11,RUNX2B,NARS2,UBE2D3,HSP70L,QRSL1,KIF2A |
Interacting Protein
NETO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NETO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NETO2.
ytpB;TIA1;WDHD1;KRT17;AIMP2;NELFCD;CCDC82;HS6ST2;TMEM168;TRMT6;IRS2
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References
- Lindstrom, SH; Ryan, DG; et al. Kainate receptor subunit diversity underlying response diversity in retinal Off bipolar cells. JOURNAL OF PHYSIOLOGY-LONDON 592:1457-1477(2014).
- Zhang, W; Devi, SPS; et al. Auxiliary proteins promote modal gating of AMPA- and kainate-type glutamate receptors. EUROPEAN JOURNAL OF NEUROSCIENCE 39:1138-1147(2014).
