NEIL3
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Official Full Name
nei endonuclease VIII-like 3 (E. coli) -
Overview
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate;the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA;strand break via the associated lyase reaction (Bandaru et al., 2002 (PubMed 12509226)). -
Synonyms
NEIL3;nei endonuclease VIII-like 3 (E. coli);endonuclease 8-like 3;FLJ10858;FPG2;hFPG2;hNEI3;123;AI449477;BC034753;C85903;DNA glycosylase FPG2;DNA glycosylase hFPG2;DNA glycosylase/AP lyase Neil3;EC 3.2.2.-;EC 4.2.99.18;Endonuclease VIII-like 3;FGP2;MGC27861;MGC36916;nei endonuclease VIII-like 3;Nei like 3 (E. coli);Nei-like protein 3;NEIL3_HUMAN;OTTHUMP00000218810;RGD1310562;NEI3
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NEIL3-10568M | Recombinant Mouse NEIL3 Protein | Mammalian Cells | Mouse | His |
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| NEIL3-1724Z | Recombinant Zebrafish NEIL3 | Mammalian Cells | Zebrafish | His |
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| NEIL3-912H | Recombinant Human NEIL3 | Mammalian Cells | Human | His |
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| NEIL3-3880HCL | Recombinant Human NEIL3 293 Cell Lysate | HEK293 | Human | Non |
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| Neil3-1446M | Recombinant Mouse Neil3 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Val2~Val187 |
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| NEIL3-3609H | Recombinant Human NEIL3 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| NEIL3-3609H-B | Recombinant Human NEIL3 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| NEIL3-6006M | Recombinant Mouse NEIL3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NEIL3-6006M-B | Recombinant Mouse NEIL3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NEIL3 involved in several pathways and played different roles in them. We selected most pathways NEIL3 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEIL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | FEN1,PARP2,NEIL2,HMGB1,POLE3,xthA,TDG.1,nth,MBD4,POLD4 |
Protein Function
NEIL3 has several biochemical functions, for example, DNA N-glycosylase activity,DNA-(apurinic or apyrimidinic site) lyase activity,bubble DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEIL3 itself. We selected most functions NEIL3 had, and list some proteins which have the same functions with NEIL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| damaged DNA binding | TRPC2,TP63,RPA2,RPS3,GTF2H3,XRCC6,DCLRE1A,TP73,APTX,APEX1 |
| single-stranded DNA binding | IGHMBP2,RAD51C,PEO1,SSBP3,OBFC2B,ERCC5,ALYREF,NABP2,YBX1,SSBP3A |
| double-stranded DNA binding | MTERFD3,RBMS1,XRCC3,MTERF2,LSM14A,CTNNB1,TRP63,AKAP8,SAFB,USF1 |
| DNA N-glycosylase activity | TDG,NEIL1,SMUG1,NTHL1,OGG1 |
| zinc ion binding | KMT2E,AGBL4,LMO4B,TRIP6,AFG3L2,SIRT2,CA7,DRP2,KMT2A,RNF139 |
| bubble DNA binding | HMGB1,ERCC5,BLM,RECQL4,WRN |
| DNA-(apurinic or apyrimidinic site) lyase activity | APLF,RPS3,HMGA1A,HMGA1,APEX1,ALKBH1,APEX2,NTHL1,HMGA1-RS1,HMGA2 |
Interacting Protein
NEIL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEIL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEIL3.
TP53;TWIST1;SF3B2;PRPF40A;SLC2A1;RBM25;SMARCA4;Ect2;SFSWAP;NNT;ROCK1;GPATCH4;RSBN1L;BCL7C;HMCES;ENY2;CDKN2AIP;GLTSCR1;SLC25A13
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