NEDD4L

  • Official Full Name

    neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

  • Overview

    NEDD4 (neural precursor expressed, developmentally down-regulated protein 4) was originally identified as a gene that is highly expressed in the early mouse embryonic central nervous system. Subsequently, a family of NEDD4-like proteins have been defined

  • Synonyms

    NEDD4L;neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase;neural precursor cell expressed, developmentally down regulated 4 like;E3 ubiquitin-protein ligase NEDD4-like;KIAA0439;NEDD4 2;RSP5;ubiquitin

Recombinant Proteins

  • Human
  • Mouse
  • HEK293
  • E.coli
  • HEK293T
  • Non
  • Myc&DDK
  • His
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
NEDD4L-3885HCL Recombinant Human NEDD4L 293 Cell Lysate HEK293 Human Non
NEDD4L-034H Recombinant Human NEDD4L Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
NEDD4L-0438H Recombinant Human NEDD4L Protein (A2-D975), Tag Free E.coli Human Non A2-D975
NEDD4L-0439H Recombinant Human NEDD4L Protein (A2-D975), His tagged E.coli Human His A2-D975
NEDD4L-4142H Recombinant Human NEDD4L Protein (Glu629-Asp975), N-His tagged E.coli Human His Glu629-Asp975
NEDD4L-4356H Recombinant Human NEDD4L protein, GST-tagged E.coli Human GST 2-975aa
Nedd4l-4360M Recombinant Mouse Nedd4l Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK

    Involved Pathway

    NEDD4L involved in several pathways and played different roles in them. We selected most pathways NEDD4L participated on our site, such as Ubiquitin mediated proteolysis,Endocytosis,Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEDD4L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aldosterone-regulated sodium reabsorption ALPHA-ENAC,PIK3CA,MAPK1,INS2,PIK3R5,ATP1B4,INS,ATP1A3,HSD11B2,MAPK3
    Ubiquitin mediated proteolysis UBE2KB,SIAH1,MAP3K1,ANAPC1,UBE2E3,UBE2Z,UBE2E2,BTRC,UBE4A,ITCH
    Endocytosis ARFGEF2,ARF6B,PDCD6IP,CAPZA2,VPS37C,ARRB2B,FOLR2,DNAJC6,RAB11AL,AP2M1B

    Protein Function

    NEDD4L has several biochemical functions, for example, ion channel binding,ligase activity,potassium channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEDD4L itself. We selected most functions NEDD4L had, and list some proteins which have the same functions with NEDD4L. You can find most of the proteins on our site.

    Function Related Protein
    sodium channel inhibitor activity SCN1B,CAMK2D,SLC14A2,PCSK9,NEDD4
    ubiquitin protein ligase activity PDZRN3B,UBE2G2,HERC5,ARIH1L,CCNB1IP1,RNF34,UBR2,FANCF,RNF25,RNF146
    ion channel binding HSP90AB1,RYR2,PDE4D,KCNJ11,FHL1,NOS1,ASPH,AASS,FGF13,SRC
    ligase activity UBE2G1A,ADSSL,RC3H2,TRIML1,UHRF1,RFFL,SMURF2,EGR2,RNF25,ZFP91
    sodium channel regulator activity YWHAH,SCLT1,PRSS30,PKP2,NOS1,SGK2B,FGF13,AGT,FXYD5,GPD1L
    ubiquitin-protein transferase activity TRIP12,ZYG11,TTC3,SKP1,MIB2,MYLIP,UBE2D4,UBR3,RNF181,SHPRH
    potassium channel regulator activity KCNAB1,AKAP9,KCNE1,ANK2,KCNIP1,KCNMB3,KCNIP2,CHP,PIAS3,SGK1
    protein binding PAIP1,HYAL2,IFT46,ZDHHC13,SEC23A,GTF2E2,BACH1,SDC2,FSD2,SPATA13
    potassium channel inhibitor activity CAV3,KCNK2,ENSA,KCNA5,PTI,RASA1

    Interacting Protein

    NEDD4L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEDD4L here. Most of them are supplied by our site. Hope this information will be useful for your research of NEDD4L.

    DAZAP2;SCNN1B;RAPGEF2;AMOT;MED28;FBXL15;ARHGDIA;YWHAG;LAPTM5;SMAD2;GORAB;WNK1;AATF;RNF11;vpr;YWHAH;TOLLIP

    Resources

    Research Area

    Parkinson's Disease Related Molecules
    Ubiquitin
    Post-translational Modification of NFkB/IkB
    Wnt Intracellular Signaling

    References

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