NEDD4L

  • Official Full Name

    neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

  • Overview

    NEDD4 (neural precursor expressed, developmentally down-regulated protein 4) was originally identified as a gene that is highly expressed in the early mouse embryonic central nervous system. Subsequently, a family of NEDD4-like proteins have been defined

  • Synonyms

    NEDD4L;neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase;neural precursor cell expressed, developmentally down regulated 4 like;E3 ubiquitin-protein ligase NEDD4-like;KIAA0439;NEDD4 2;RSP5;ubiquitin

Recombinant Proteins

  • Human
  • Mouse
  • HEK293
  • E.coli
  • Non
  • DDK
  • Myc
  • His
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
NEDD4L-3885HCL Recombinant Human NEDD4L 293 Cell Lysate HEK293 Human Non
NEDD4L-034H Recombinant Human NEDD4L Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
NEDD4L-0438H Recombinant Human NEDD4L Protein (A2-D975), Tag Free E.coli Human Non A2-D975
NEDD4L-0439H Recombinant Human NEDD4L Protein (A2-D975), His tagged E.coli Human His A2-D975
NEDD4L-4142H Recombinant Human NEDD4L Protein (Glu629-Asp975), N-His tagged E.coli Human His Glu629-Asp975
NEDD4L-4356H Recombinant Human NEDD4L protein, GST-tagged E.coli Human GST 2-975aa
Nedd4l-4360M Recombinant Mouse Nedd4l Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    NEDD4L involved in several pathways and played different roles in them. We selected most pathways NEDD4L participated on our site, such as Ubiquitin mediated proteolysis,Endocytosis,Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEDD4L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis PARK2,ITCH,UBE2D2A,BTRC,ANAPC1,UBE1Y1,FZR1,UBE2L3B,UBA2,HUWE1
    Endocytosis RAB5AB,HSP70L,GIT2A,GRK1A,CHMP4C,ARFGAP2,GRK1,ARPC1A,RAB11FIP5,RNF103-CHMP3
    Aldosterone-regulated sodium reabsorption ATP1A4,SCNN1B,PIK3CB,PRKCB,ATP1B2,SLC9A3R2,PIK3R3,KRAS,INS2,PRKCA

    Protein Function

    NEDD4L has several biochemical functions, for example, ion channel binding,ligase activity,potassium channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEDD4L itself. We selected most functions NEDD4L had, and list some proteins which have the same functions with NEDD4L. You can find most of the proteins on our site.

    Function Related Protein
    ion channel binding KCNH5,PHPT1,EPN1,AKAP6,KCNC1,DLG1,YWHAH,PKP2,PACS1A,PACS2
    ligase activity GLULB,SH3RF2,HECW1,LIPT2,AMFR,ZNRF1,HACE1,UBE2NB,HERC5,TTLL13
    ubiquitin-protein transferase activity RNF152,KLHL20,BIRC5,RNF41,UBE3C,SKP1,BIRC5B,UBA7,MARCH5L,TRIM17
    sodium channel inhibitor activity CAMK2D,PCSK9,SCN1B,NEDD4,SLC14A2
    protein binding ALKBH6,PPP6R2,TAC3,SETX,CCDC42,CD1B,SMARCAL1,VHL,STON2,SPCS1
    sodium channel regulator activity FGF12,PKP2,FGF13,FXYD3,RANGRF,SGK2A,SCN1BA,PTPN3,GPD1L,SCN3B
    potassium channel regulator activity KCNAB1,DRD2,LRRC26,KCNIP4,DPP6,ANK2,KCNAB2,SUMO1,KCNMB1,KCNMB2
    ubiquitin protein ligase activity ZNRF2,SIAH1,TRIM2,FBXO40,RNF7,RNF180,SMURF1,RNF144B,RNF19B,MED21
    potassium channel inhibitor activity KCNK2,RASA1,ENSA,CAV3,PTI,KCNA5

    Interacting Protein

    NEDD4L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEDD4L here. Most of them are supplied by our site. Hope this information will be useful for your research of NEDD4L.

    DAZAP2;SCNN1B;RAPGEF2;AMOT;MED28;FBXL15;ARHGDIA;YWHAG;LAPTM5;SMAD2;GORAB;WNK1;AATF;RNF11;vpr;YWHAH;TOLLIP

    Resources

    Research Area

    Parkinson's Disease Related Molecules
    Ubiquitin
    Post-translational Modification of NFkB/IkB
    Wnt Intracellular Signaling

    References

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