NDUFV2
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Official Full Name
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -
Overview
The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. T -
Synonyms
NDUFV2;NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa;NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial;mitochondrial;24kDa subunit of Complex I;CI-24k;NADH dehydrogenase [ubiquinone] flavoprotein 2;NADH ubiquinone oxidoreductase 24 kDa subunit;NADH-ubiquinone oxidoreductase 24 kDa subunit;NDUV2_HUMAN;Ubiquinoneflavoprotein 2, mitochondrial precursor;NADH dehydrogenase subunit II;NADH dehydrogenase flavoprotein 2;NADH-ubiquinone reductase 24 kDa mitochondrial
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
NDUFV2 involved in several pathways and played different roles in them. We selected most pathways NDUFV2 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFV2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | DRD1A,CYCS,ATP5J,UQCRC2,SDHC,UBE1Y1,ATP5D,NDUFA4,UQCR11,NDUFB9 |
| Huntingtons disease | BBC3,TBPL1,DNAIC2,COX7B2,ATP5H,COX7A2L,DNAH5,NDUFA4,DNAI2,ATP5G1 |
| Alzheimers disease | NDUFA2,GRIN2C,NDUFB2,CALML5,UQCRH,NDUFA11,GSK3B,NDUFA12,PPP3CB,NDUFA1 |
| Oxidative phosphorylation | SDHA,ATP6V0A4,NDUFA11,NDUFA9,COX5AA,NDUFS6,ATP12A,NDUFS4,NDUFB5,ATP6V1C1 |
| Non-alcoholic fatty liver disease (NAFLD) | COX7A2,IRS2,NDUFB10,UQCRQ,COX7B,PRKAA1,INS,UQCR11,SDHC,NDUFB11 |
| Metabolic pathways | UQCR10,DLDH,ATP6V0D1,NDUFB8,GALE,ATP6V1B1,ST3GAL3B,HSD3B1,RDH8B,AKR1B1 |
Protein Function
NDUFV2 has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding,NADH dehydrogenase (ubiquinone) activity,electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFV2 itself. We selected most functions NDUFV2 had, and list some proteins which have the same functions with NDUFV2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | HDAC5,NRXN1,ARAP3,ZFAND5A,MFNG,ZFP830,ZBTB8B,REV3L,PRKCBP1L,ZNF79 |
| electron carrier activity | ASPH,GLDC,CIAPIN1,GCDHA,ACADVL,ACADL,COX7A2A,PRKRA,GLRX2,GPX2 |
| 2 iron, 2 sulfur cluster binding | XDH,CIAPIN1,AOX1,FDX1L,AIFM4,GLRX5,AOX3,FECH,UQCRFS1,CISD1 |
| NADH dehydrogenase (ubiquinone) activity | NDUFB4,NDUFS6,NDUFA8,NDUFA13,NDUFS1,NDUFA2,NDUFA7,NDUFS5,NDUFA3,NDUFA5 |
Interacting Protein
NDUFV2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFV2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFV2.
NDUFA9;NDUFS2;NDUFS3;NDUFA2;CRMP1;KAT5;SP110;NDUFS4;NDUFS5;NDUFS6;FN1;MT-ND5;NDUFS1
Resources
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References
- Funayama, M; Ohashi, S; et al. Analyses of sensitivity to MPTP in NDUFV2(+/-) mice. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 128:170-171(2008).
