NDUFB7
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Official Full Name
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -
Overview
The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. -
Synonyms
NDUFB7;NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa;NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7 (18kD, B18);NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7;B18;CI B18;complex I B18 subunit;MGC2480;NADH ubiquinone oxidoreductase B18 subunit;1110002H15Rik;Cell adhesion protein SQM1;Complex I B18;NADH dehydrogenase (ubiquinone) 1 beta subcomplex 7 18kDa;NADH dehydrogenase (ubiquinone) 1 beta subcomplex 7;complex I-B18;NADH-ubiquinone oxidoreductase B18 subunit;CI-B18
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NDUFB7 involved in several pathways and played different roles in them. We selected most pathways NDUFB7 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFB7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-alcoholic fatty liver disease (NAFLD) | NDUFS3,UQCRB,IL6R,PRKAG2,CYCS,PRKAB2,NDUFS7,COX4I2,NDUFS6,UQCRC2 |
| Oxidative phosphorylation | ATP6V1C2,ATP5D,ATP5L,NDUFS6,ATP5J2,MT-ND4,ATP5B,PPA2,UQCRB,ATP6V1G2 |
| Metabolic pathways | PPAP2CB,ACY1,AOC3,ACLYA,ALOX12,MDH1AA,DHODH,MTMR7,NDUFA11,RPN1 |
| Parkinsons disease | NDUFA12,GNAI2,GPR37,UQCRC2,PARK7,PINK1,COX4I2,NDUFA5,UQCR11,NDUFS2 |
| Huntingtons disease | CREB3L1,NDUFS3,COX5B,ITPR1,BBC3,NDUFA7,COX4I2,APAF1,NDUFS2,COX4I1 |
| Alzheimers disease | LPL,NDUFS7,UQCRQ,CALM4,ITPR3,ADAM10,ATP5J,NDUFA9,COX6C,COX7A2L |
Protein Function
NDUFB7 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFB7 itself. We selected most functions NDUFB7 had, and list some proteins which have the same functions with NDUFB7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADH dehydrogenase (ubiquinone) activity | NDUFA9,NDUFS4,NDUFA13,NDUFAF2,NDUFB5,NDUFB6,NDUFV1,NDUFV2,NDUFB3,NDUFB2 |
Interacting Protein
NDUFB7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFB7 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFB7.
NDUFA2;MAK;CKAP4;MLKL;NDUFS5;NDUFS3;RAB5C;RAB7A;NDUFA6;NDUFA9;MMGT1;Tmed2;NDUFA12;GOLT1B
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References
- Lee, BH; Kim, JH; et al. The early molecular processes underlying the neurological manifestations of an animal model of Wilson's disease. METALLOMICS 5:532-540(2013).
- Henningsen, K; Palmfeldt, J; et al. Candidate Hippocampal Biomarkers of Susceptibility and Resilience to Stress in a Rat Model of Depression. MOLECULAR & CELLULAR PROTEOMICS 11:-(2012).
