NDUFA8
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Official Full Name
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -
Overview
The protein encoded by this gene belongs to the complex I 19 kDA subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. -
Synonyms
NDUFA8;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8 (19kD, PGIV);NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8;complex I PGIV subunit;MGC793;PGIV;complex I-19kD;c
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NDUFA8-1226H | Recombinant Human NDUFA8, GST-tagged | E.coli | Human | GST | 1-172aa | |
| NDUFA8-10522M | Recombinant Mouse NDUFA8 Protein | Mammalian Cells | Mouse | His |
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| NDUFA8-10991Z | Recombinant Zebrafish NDUFA8 | Mammalian Cells | Zebrafish | His |
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| NDUFA8-129H | Recombinant Human NDUFA8 Protein, His-tagged | E.coli | Human | His |
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| NDUFA8-5033C | Recombinant Chicken NDUFA8 | Mammalian Cells | Chicken | His |
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| NDUFA8-5034C | Recombinant Chicken NDUFA8 | Mammalian Cells | Chicken | His |
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| NDUFA8-3915HCL | Recombinant Human NDUFA8 293 Cell Lysate | HEK293 | Human | Non |
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| Ndufa8-4332M | Recombinant Mouse Ndufa8 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| NDUFA8-5973M | Recombinant Mouse NDUFA8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NDUFA8-5973M-B | Recombinant Mouse NDUFA8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NDUFA8 involved in several pathways and played different roles in them. We selected most pathways NDUFA8 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | HYAL4,ACOX2,ALG9,RPIA,GFPT1,GNE,PTGES,CAD,UQCRC2B,FUT1 |
| Alzheimers disease | NDUFA4L2,NDUFC1,NDUFA3,MT-ATP6,COX4I1,NDUFS2,NCSTN,ITPR1,NDUFS4,IL1B2 |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFB6,INSR,PIK3CG,UQCRB,Fasl,MAP3K11,IL-8,NDUFB9,COX8C,COX7B2 |
| Huntingtons disease | NDUFA5,GNAQ,DNAL1,NDUFS6,SOD2,COX6A2,mt-Atp8,HDAC1,TBPL2,COX7A2L |
| Oxidative phosphorylation | NDUFB3,NDUFS1,NDUFA4L,COX15,COX5A,Atp5g2,ATP6V1AA,COX7B2,ATP5J2,NDUFB7 |
| Parkinsons disease | NDUFA9,SLC6A3,MT-ND4,SLC25A31,NDUFC1,CASP9,ATP5G3,COX6B2,ATP5D,ATP5G1 |
Protein Function
NDUFA8 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFA8 itself. We selected most functions NDUFA8 had, and list some proteins which have the same functions with NDUFA8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | MLKL,ULK1,TULP3,TRAF2,SHANK1,ANKRD32,PDCL,GNB1,C8G,CDKN1A |
| NADH dehydrogenase (ubiquinone) activity | NDUFB1,NDUFB5,NDUFAF2,NDUFS8,NDUFV3,NDUFA4,NDUFS7,NDUFA2,NDUFS4,NDUFB6 |
Interacting Protein
NDUFA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFA8.
NDUFA2;NDUFS3;TBC1D4;MYC;RAB7A;NDUFA6;ATM;KLC3;P;NDUFA11;CNTROB;NDUFAF3;TIMMDC1;GOLT1B
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References
- Jesinkey, SR; Korrapati, MC; et al. Atomoxetine Prevents Dexamethasone-Induced Skeletal Muscle Atrophy in Mice. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 351:663-673(2014).
- Garrett, SM; Whitaker, RM; et al. Agonism of the 5-Hydroxytryptamine 1F Receptor Promotes Mitochondrial Biogenesis and Recovery from Acute Kidney Injury. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 350:257-264(2014).
