NCOA4
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Official Full Name
nuclear receptor coactivator 4 -
Overview
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. -
Synonyms
NCOA4;nuclear receptor coactivator 4;ARA70;DKFZp762E1112;ELE1;PTC3;RET activating gene ELE1;RFG;NCoA-4;ret fused;70 kDa AR-activator;RET-activating gene ELE1;70 kDa androgen receptor coactivator;androgen receptor-associated protein of 70 kDa
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NCOA4-1214H | Recombinant Human NCOA4, His-tagged | E.coli | Human | His | N-term-400aa | |
| NCOA4-11351Z | Recombinant Zebrafish NCOA4 | Mammalian Cell | Zebrafish | His |
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| NCOA4-1634C | Recombinant Chicken NCOA4 | Mammalian Cell | Chicken | His |
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| NCOA4-3940HCL | Recombinant Human NCOA4 293 Cell Lysate | HEK293 | Human | Non |
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| NCOA4-423H | Recombinant Human NCOA4 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Ncoa4-4315M | Recombinant Mouse Ncoa4 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
NCOA4 involved in several pathways and played different roles in them. We selected most pathways NCOA4 participated on our site, such as Pathways in cancer,Thyroid cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCOA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid cancer | RET,PAX8,LEF1,MAPK3,TP53,NRAS,NTRK1,TCF7,TPR,KRAS |
| Pathways in cancer | F2R,KITLG,RALB,RALGDS,KRAS,STK36,TRAF4,VEGFB,PTCH1,FGF20 |
Protein Function
NCOA4 has several biochemical functions, for example, androgen receptor binding,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NCOA4 itself. We selected most functions NCOA4 had, and list some proteins which have the same functions with NCOA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | E4F1,RNF14,MTA1,SMARCA2,TAF11,CTNNB1,PMF1,PPARGC1A,SAP130,UBE2L3 |
| androgen receptor binding | PRPF6,WIPI1,SMARCA4,RNF14,CALR,NRIP1,DDX5,RNF6,CDK7,CCNE1 |
Interacting Protein
NCOA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCOA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCOA4.
AR;AKT1;q81sn0_bacan;spoIVA;ATXN2;PSMD14;PSMC1;USP43;Psmd6
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References
- Harada, K; Kakuda, Y; et al. Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. JOURNAL OF CLINICAL PATHOLOGY 67:396-402(2014).
- Chien, CD; Kirilyuk, A; et al. Role of the Nuclear Receptor Coactivator AIB1-Delta 4 Splice Variant in the Control of Gene Transcription. JOURNAL OF BIOLOGICAL CHEMISTRY 286:26813-26827(2011).
