NBEA
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Official Full Name
neurobeachin -
Overview
This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined. -
Synonyms
NBEA;neurobeachin;BCL8B;FLJ10197;KIAA1544;Lysosomal trafficking regulator 2;LYST2;Protein BCL8B;Protein neurobeachin;RP11-270C18.1;lysosomal-trafficking regulator 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NBEA-10446M | Recombinant Mouse NBEA Protein | Mammalian Cells | Mouse | His |
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| NBEA-4550C | Recombinant Chicken NBEA | Mammalian Cells | Chicken | His |
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| NBEA-5924M | Recombinant Mouse NBEA Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NBEA-5924M-B | Recombinant Mouse NBEA Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NBEA involved in several pathways and played different roles in them. We selected most pathways NBEA participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NBEA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
NBEA has several biochemical functions, for example, phospholipid binding,protein kinase A binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NBEA itself. We selected most functions NBEA had, and list some proteins which have the same functions with NBEA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phospholipid binding | NBEAL2,GRK5,PLEKHA3,TEC,NSFL1C,NSMAF,Defa4,SPTB,ABCA1,FABP1 |
| protein kinase A binding | AKAP7,AKAP5,DACT3,RARA,AKAP12,AKAP12B,DACT1,LRRK2,AKAP13,Akap3 |
| protein kinase binding | CACNB3,CCNE1,C10orf46,MAPK6,ATG13,HIF1A,RNF138,MVP,FAM83D,CALM2 |
Interacting Protein
NBEA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NBEA here. Most of them are supplied by our site. Hope this information will be useful for your research of NBEA.
Ywhae;BMPR2;Ywhab
Resources
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References
- Kitagishi, Y; Minami, A; et al. Neuron Membrane Trafficking and Protein Kinases Involved in Autism and ADHD. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16:3095-3115(2015).
- Dobson, AJ; Chaston, JM; et al. Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster. NATURE COMMUNICATIONS 6:-(2015).
