MYPN
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Official Full Name
myopalladin -
Overview
Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently.;Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin,;nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which;interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene;product can interact with a protein with the I-band indicating it has a regulatory as well as structural function.;Alternative splicing results in multiple transcript variants. -
Synonyms
MYPN;myopalladin;MYOP;sarcomeric protein myopalladin;145 kDa;145 kDa sarcomeric protein;MYPN_HUMAN;OTTHUMP00000019694;OTTHUMP00000019695;sarcomeric protein myopalladin, 145 kDa (MYOP)
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- His
- Myc&DDK
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MYPN-551H | Recombinant Human MYPN Protein, His-tagged | E.coli | Human | His | Pro945~Leu1320 | |
| MYPN-10359M | Recombinant Mouse MYPN Protein | Mammalian Cells | Mouse | His |
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| MYPN-2501H | Recombinant Human MYPN Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| MYPN-5861H | Recombinant Human MYPN Protein, GST-tagged | Wheat Germ | Human | GST |
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| MYPN-5872M | Recombinant Mouse MYPN Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MYPN-5872M-B | Recombinant Mouse MYPN Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| MYPN-797H | Recombinant Human MYPN Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
MYPN involved in several pathways and played different roles in them. We selected most pathways MYPN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MYPN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MYPN has several biochemical functions, for example, SH3 domain binding,actin binding,cytoskeletal protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYPN itself. We selected most functions MYPN had, and list some proteins which have the same functions with MYPN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| muscle alpha-actinin binding | PKD2L1,TTN,PALLD,PDLIM2,PKD2,LDB3,NRAP |
| actin binding | VMHC,HIP1RB,LRRK2,DBNL,TNNT2A,RUSC1,MYRIP,PHACTR3B,MKL1,FGD4 |
| cytoskeletal protein binding | FLNC,CAPN2,ANXA2,PACSIN3,SLC8A1,FRMD5,Fert2,CDK5,DES,DYNLL2 |
| SH3 domain binding | INPPL1,DRD4,PLSCR4,MAPT,ELMO1,SH3BGR,SHANK3,INPP5D,OSTF1,ELMO2 |
Interacting Protein
MYPN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYPN here. Most of them are supplied by our site. Hope this information will be useful for your research of MYPN.
Resources
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References
- Huby, AC; Mendsaikhan, U; et al. Disturbance in Z-Disk Mechanosensitive Proteins Induced by a Persistent Mutant Myopalladin Causes Familial Restrictive Cardiomyopathy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 64:2765-2776(2014).
- Elliott, P; et al. Paving the Way for Novel Treatment Strategies in Genetic Cardiomyopathies. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 64:2777-2778(2014).
