MYO1A
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Official Full Name
myosin IA -
Overview
The protein encoded by this gene belongs to the myosin superfamily. Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. Each myosin has a conserved N-terminal motor domain that contains both ATP-binding and actin-binding sequences. Following the motor domain is a light-chain-binding neck region containing 1-6 copies of a repeat element, the IQ motif, that serves as a binding site for calmodulin or other members of the EF-hand superfamily of calcium-binding proteins. At the C-terminus, each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets each myosin to its particular subcellular location. The kidney epithelial cell line, LLC-PK1-CL4 (CL4), forms a well ordered brush border (BB) on its apical surface. Experiments indicate that the brush border population of the encoded protein turns over rapidly, while its head and tail domains interact transiently with the core actin and plasma membrane, respectively. A rapidly exchanging pool of the protein encoded by this gene envelops an actin core bundle that, by comparison, is static in structure. -
Synonyms
MYO1A;myosin IA;DFNA48, MYHL;myosin-Ia;BBM I;BBM-I;BBMI;Brush border myosin I;DFNA48;MIHC;MYHL;MYO1A_HUMAN;Myosin I heavy chain;Myosin, heavy polypeptide like (100kD);brush border myosin-I;myosin, heavy polypeptide-like (100kD)
Recombinant Proteins
- Mouse
- Human
- Chicken
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- His
- Non
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MYO1A-10333M | Recombinant Mouse MYO1A Protein | Mammalian Cells | Mouse | His |
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| MYO1A-30273TH | Recombinant Human MYO1A | Wheat Germ | Human | Non | 100 amino acids |
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| MYO1A-537H | Recombinant Human MYO1A Protein, His-tagged | E.coli | Human | His | Lys781~Gln1043 |
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| Myo1a-538M | Recombinant Mouse Myo1a Protein, His-tagged | E.coli | Mouse | His | Met783~Arg1043 |
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| MYO1A-6719C | Recombinant Chicken MYO1A | Mammalian Cells | Chicken | His |
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| MYO1A-4010HCL | Recombinant Human MYO1A 293 Cell Lysate | HEK293 | Human | Non |
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| MYO1A-5307H | Recombinant Human MYO1A protein, His-tagged | E.coli | Human | His | 1-350 aa |
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| MYO1A-5830H | Recombinant Human MYO1A Protein, GST-tagged | Wheat Germ | Human | GST |
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| MYO1A-5857M | Recombinant Mouse MYO1A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MYO1A-5857M-B | Recombinant Mouse MYO1A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MYO1A involved in several pathways and played different roles in them. We selected most pathways MYO1A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MYO1A has several biochemical functions, for example, ATP binding,actin filament binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO1A itself. We selected most functions MYO1A had, and list some proteins which have the same functions with MYO1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | FARSB,TOR1,MAPK7,KIF23,NDUFA13,CHD9,CMPK,P2RY1,MYO6A,ATP6V1A |
| actin filament binding | FSCN2A,ADD1,SCIN,PPP1R9B,TRIOBPB,VCLA,CTNNA3,ESPN,WIPF3,ERMN |
| motor activity | SMYHC1,KLC1,DYNC2H1,MYH1B,MYO10,KIF2A,MYO7B,DYNLL1,MYH7B,MYO5A |
| calmodulin binding | SMTNL1,MARCKS,MKNK2,CNN3A,MAPKAPK2,MYH1B,CAMSAP1,CAMK2D,SLC8A2,MYO3A |
Interacting Protein
MYO1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO1A here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO1A.
MAP3K3;NEK6;USP20;PHLDA3;KIF1C;GRB2
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