MYL3
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Official Full Name
myosin, light chain 3, alkali; ventricular, skeletal, slow -
Overview
MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. -
Synonyms
MYL3;myosin, light chain 3, alkali;ventricular, skeletal, slow;myosin, light polypeptide 3, alkali;ventricular, skeletal, slow;myosin light chain 3;CMH8;MLC1SB;MLC1V;VLC1;CMLC1;cardiac myosin light chain 1;ventricular/slow twitch myosin alkali
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Bovine
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- GST&His
- Non
- Avi&Fc&His
- DDK&Myc
- Flag
- His&Myc
Involved Pathway
MYL3 involved in several pathways and played different roles in them. We selected most pathways MYL3 participated on our site, such as Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes,Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with MYL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adrenergic signaling in cardiomyocytes | PPP2R1B,ATP1B2,ATP1A4,PRKACA,CALM,ATP1A3B,CACNA1DA,PIK3CG,CACNA2D4,PRKACAB |
| Cardiac muscle contraction | UQCR11,ATP1B1A,COX5A,ATP1A4,CACNA1SA,CACNG7A,MYL2B,TPM2,CACNG2A,ATP1A1B |
| Hypertrophic cardiomyopathy (HCM) | ITGA6,ITGA2B,SGCD,PRKAA2,CACNB3,ITGB3,TPM2,CACNG1,ACE,EMD |
| Dilated cardiomyopathy | LAMA2,PRKACB,CACNA2D1,ADRB1,ACTG1,ITGB8,CACNG2,TPM2,ITGB3,ITGA2 |
Protein Function
MYL3 has several biochemical functions, for example, actin monomer binding,calcium ion binding,motor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYL3 itself. We selected most functions MYL3 had, and list some proteins which have the same functions with MYL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin monomer binding | CORO1A,TMSB4X,PFN1,TMSB15B,PFN4,MYL4,MKL1,ABL2,ABL1,MYL2 |
| myosin II heavy chain binding | MYL4 |
| calcium ion binding | aLA,EGFL6,SLIT3,F9A,FBLN2,NECAB3,EYS,FAM20C,LRP4,FSTL5 |
| structural constituent of muscle | ACTN2,MYLPF,MYOM1,DMD,TTN,NEBL,MYOT,TCAP,NEXN,MYL1 |
| motor activity | MYHC4,DYNLT1,MYO7A,MYO10,DYNLRB1,DNALC4,CGNB,MYH1,MYHZ1.2,DYNC2LI1 |
Interacting Protein
MYL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYL3.
Mylk;FTH1;ATG101;YWHAZ
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