MYH11

  • Official Full Name

    myosin, heavy chain 11, smooth muscle

  • Overview

    The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product;is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light;chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through;the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this;gene, and its 3 end overlaps with that of the latter. The pericentric inversion of chromosome 16 (inv(16)(p13q22));produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of;core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This;chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing;generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation.;Alternatively spliced transcript variants encoding different isoforms have been identified.

  • Synonyms

    MYH11;myosin, heavy chain 11, smooth muscle;myosin, heavy polypeptide 11, smooth muscle;myosin-11;SMHC;SMMHC;myosin heavy chain 11;myosin heavy chain, smooth muscle isoform;AAT4;FAA4;FLJ35232;MGC32963;MGC126726;DKFZp686D10126;DKFZp686D19237
Cat.# Product name Source (Host) Species Tag Protein Length Price
MYH11-1132H Recombinant Human MYH11, His-tagged E.coli Human His 1215-1323aa
MYH11-6826C Recombinant Chicken MYH11 Mammalian Cells Chicken His
Myh11-8024R Recombinant Rat Myh11 protein, His-tagged E.coli Rat His Lys211~Trp482
Myh11-1807R Recombinant Rat Myh11 Protein, His-tagged E.coli Rat His Met1-Ser351
MYH11-301534H Recombinant Human MYH11 protein, GST-tagged E.coli Human GST Leu1208-Gln1316

    Involved Pathway

    MYH11 involved in several pathways and played different roles in them. We selected most pathways MYH11 participated on our site, such as Vascular smooth muscle contraction,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYH11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Vascular smooth muscle contraction PPP1CA,MYL9A,ITPR1,CALM2,CALM1B,RHOAB,PPP1CB,RHOAD,AGTR1B,PRKCBB
    Tight junction CLDND,CSDA,ASH1L,MYH1B,SHROOM2,RHOA,PPP2R2D,MYLPFA,SHROOM3,HRAS

    Protein Function

    MYH11 has several biochemical functions, for example, ATP binding,actin filament binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYH11 itself. We selected most functions MYH11 had, and list some proteins which have the same functions with MYH11. You can find most of the proteins on our site.

    Function Related Protein
    motor activity MYO1H,MYO1EB,MYH7B,MYH8,DYNLL1,MYO10,MYO5A,SMYHC1,MYH9,MYH11A
    structural constituent of muscle CSRP3,MYL9,MYBPC3,MYLPF,NEBL,MYL2,SMTN,MYOM1,MYBPC1,TCAP
    actin filament binding ARPC1A,SYNE1,RCSD1,MACF1,ABL2,MYO6,EZR,CTNNA2,FSCN2A,SHROOM1
    calmodulin binding NRGN,PCP4,CAMK4,MAP6D1,SLC14A2,MYH4,MKNK2B,CNN2,CAMK2D,ATP2B4
    ATP binding NUAK2,ATP9A,BMPR2B,DNAHC8,NLRP14,HLTF,CSK,DDX49,JAK2B,Abcb1b
    protein binding NFU1,SCEL,RNF13,SMU1,SYCE1,SLC25A23,AGRN,ZNF148,GSE1,RRP7A

    Interacting Protein

    MYH11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYH11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYH11.

    MYL12B;WRAP73;GAMMAHV.ORF40;APC;GRB2;DAXX;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;TBC1D31;ARPC5;SVIL;C4BPA;FLNA;CAPZB;MYL6;ACTR3;YWHAE;YWHAZ;UBXN2A;GTF2B

    Resources

    References

    • Chen, XY; Li, R; et al. Identification of differentially expressed genes in hypothalamus of chicken during cold stress. MOLECULAR BIOLOGY REPORTS 41:2243-2248(2014).
    • Gonzalez, L; Eiro, N; et al. Clinical significance of myosin in colorectal cancer. ANNALS OF DIAGNOSTIC PATHOLOGY 16:260-266(2012).

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