MYH10
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Official Full Name
myosin, heavy chain 10, non-muscle -
Overview
Myosins comprise a family of ATP-dependent motor proteins and are best known for their role in muscle contraction and their involvement in a wide range of other eukaryotic motility processes. They are responsible for actin-based motility. The term was originally used to describe a group of similar ATPases found in striated and smooth muscle cells. Following the discovery by Pollard and Korn of enzymes with myosin-like function in Acanthamoeba castellanii, a large number of divergent myosin genes have been discovered throughout eukaryotes. Thus, although myosin was originally thought to be restricted to muscle cells (hence, "myo"), there is no single "myosin" but rather a huge superfamily of genes whose protein products share the basic properties of actin binding, ATP hydrolysis (ATPase enzyme activity), and force transduction. Virtually all eukaryotic cells contain myosin isoforms. Some isoforms have specialized functions in certain cell types (such as muscle), while other isoforms are ubiquitous. The structure and function of myosin is strongly conserved across species, to the extent that rabbit muscle myosin II will bind to actin from an amoeba. -
Synonyms
Cellular myosin heavy chain;Cellular myosin heavy chain type B;Cellular myosin heavy chain type B type B;MGC134913;MGC134914;MYH 10;Myh10;MYH10_HUMAN;Myosin 10;Myosin heavy chain 10;Myosin heavy chain 10 non muscle;Myosin heavy chain;Myosin heavy chain non muscle 11b;<br/>Myosin heavy chain nonmuscle IIb;Myosin heavy chain nonmuscle type B;Myosin heavy polypeptide 10 non muscle;Myosin-10;Myosin10;NMMHC B;<br/>NMMHC II b;NMMHC II-b;NMMHC IIB;NMMHC-B;NMMHC-IIB;NMMHCB;Non muscle myosin heavy chain B;Non muscle myosin heavy chain IIB;Non muscle myosin II heavy chain B;non-muscle IIb;Non-muscle myosin heavy chain B;Non-muscle myosin heavy chain IIb;Nonmuscle myosin heavy chain B;Nonmuscle myosin heavy chain IIB;Nonmuscle myosin II heavy chain B;type B;cytoplasmic nonmuscle myosin II
Recombinant Proteins
- Human
- Rat
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- His
- Myc&DDK
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MYH10-29710TH | Recombinant Human MYH10, His-tagged | E.coli | Human | His | 1506-1976 a.a. |
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| MYH10-3846R | Recombinant Rat MYH10 Protein | Mammalian Cells | Rat | His |
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| MYH10-7023C | Recombinant Chicken MYH10 | Mammalian Cells | Chicken | His |
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| MYH10-01H | Recombinant Human MYH10 Over-expression Lysate, Myc/DDK-tagged | HEK293 | Human | Myc&DDK |
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| MYH10-33H | Recombinant Human MYH10 protein, His-T7-tagged | E.coli | Human | His&T7 | Thr438~Lys716 |
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| MYH10-3505R | Recombinant Rat MYH10 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| MYH10-3505R-B | Recombinant Rat MYH10 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| MYH10-4645H | Recombinant Human MYH10 Protein (His438-Pro716), N-His tagged | E.coli | Human | His | His438-Pro716 |
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Involved Pathway
MYH10 involved in several pathways and played different roles in them. We selected most pathways MYH10 participated on our site, such as Tight junction,Regulation of actin cytoskeleton,Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYH10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | FGF12A,WASLA,FGF1A,ARPC5L,FGF6B,FGF10,PAK2,ACTB2,ITGA2B,MYL5 |
| Salmonella infection | CDC42L,RILP,ACTB,MAPK12A,CCL3L1,IL1B,ARPC5LA,IFNGR2,RAC1A,KLC2 |
| Tight junction | PPP2R2D,VMHCL,CLDN2,GNAI2,CLDN16,CLDN17,PRKCE,LLGL2,RHOAC,PRKCBA |
Protein Function
MYH10 has several biochemical functions, for example, ADP binding,ATP binding,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYH10 itself. We selected most functions MYH10 had, and list some proteins which have the same functions with MYH10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MCM3,UBE2D1B,MYO7B,JAK3,CDK5,C22orf28,CCT8,LIMK1,AGK,GUCY2F |
| contributes_to actin filament binding | ACTR3,ARPC3,MYH9,ACTR2,ARPC4,ARPC5,ARPC2,ARPC1B |
| calmodulin binding | MAP6D1,MAP2,ADD3,SPTAN1,CNN3,ITPKC,CAMKK2,CAMK2B1,MARCKSA,MKNK2B |
| microfilament motor activity | MYO3A,MYH9,STRC,MYH13,MYO5A,MYH3,MYO5B,MYO1E,MYO1D,MYH7 |
| ADP binding | ME1,ATP1A1,CYB5R3,PRKAG1,HSP104,PKM,ABCG1,MYO6,ADCK3,MYO18A |
| contributes_to actin-dependent ATPase activity | MYH9 |
| protein binding | ZNF581,CFTR,C4orf26,SLX4IP,ADAMTS3,NUAK1,MLH3,CD86,CRADD,ZFPL1 |
| actin filament binding | MYH3,MYH9A,CTNNA2,FSCN2B,SYNE1,TAGLN3B,GAS7,DBNLB,HIST1H2AH,USH1C |
| actin-dependent ATPase activity | MYO7A,MYH9,MYO3A,MYO1D,MYL6,MYH7,MYO1C |
Interacting Protein
MYH10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYH10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYH10.
IKBKE;VCAM1;SVIL;TRPM7;TRPM6;IKBKB;CHUK;RIPK2;EPB41;TNFRSF1A;TNFRSF1B;MCC;RELA;PAK2;MAP3K1
Resources
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References
- Strick, DJ; Feng, W; et al. Mertk Drives Myosin II Redistribution during Retinal Pigment Epithelial Phagocytosis. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 50:2427-2435(2009).
- HOROWITZ, A; TRYBUS, KM; et al. INHIBITION OF SMOOTH-MUSCLE MYOSINS ACTIVITY AND ASSEMBLY BY AN ANTIROD MONOCLONAL-ANTIBODY. JOURNAL OF BIOLOGICAL CHEMISTRY 267:26091-26096(1992).
- TRUONG, T; MEDLEY, QG; et al. ACTIN-ACTIVATED MG-ATPASE ACTIVITY OF DICTYOSTELIUM MYOSIN-II - EFFECTS OF FILAMENT FORMATION AND HEAVY-CHAIN PHOSPHORYLATION. JOURNAL OF BIOLOGICAL CHEMISTRY 267:9767-9772(1992).
