MYB

  • Official Full Name

    v-myb myeloblastosis viral oncogene homolog (avian)

  • Overview

    This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.

  • Synonyms

    MYB;v-myb myeloblastosis viral oncogene homolog (avian);v myb avian myeloblastosis viral oncogene homolog;transcriptional activator Myb;c myb;c-myb8B_CDS;c-myb10A_CDS;c-myb13A_CDS;c-myb14A_CDS;proto-oncogene c-Myb;c-myb protein (140 AA);efg;Cm

Recombinant Proteins

  • Mouse
  • Human
  • Chicken
  • Mammalian Cells
  • E.coli
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • His&T7
  • Non
  • GST
  • Avi&Fc&His
Cat.# Product name Source (Host) Species Tag Protein Length Price
MYB-10279M Recombinant Mouse MYB Protein Mammalian Cells Mouse His
MYB-1443H Recombinant Human MYB protein, His & T7-tagged E.coli Human His&T7 Thr305~Gln558
Myb-1444M Recombinant Mouse Myb protein, His & T7-tagged E.coli Mouse His&T7 Lys35~Lys291
MYB-28009TH Recombinant Human MYB Wheat Germ Human Non 640 amino acids
MYB-6858C Recombinant Chicken MYB Mammalian Cells Chicken His
MYB-4045HCL Recombinant Human MYB 293 Cell Lysate HEK293 Human Non
MYB-322HF Recombinant Full Length Human MYB Protein In Vitro Cell Free System Human Full L. 640 amino acids
MYB-4635H Recombinant Human MYB Protein (Thr305-Gln558), N-His tagged E.coli Human His Thr305-Gln558
MYB-5777H Recombinant Human MYB Protein, GST-tagged Wheat Germ Human GST
MYB-5827M Recombinant Mouse MYB Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
MYB-5827M-B Recombinant Mouse MYB Protein Pre-coupled Magnetic Beads HEK293 Mouse
MYB-6649HF Recombinant Full Length Human MYB Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 640 amino acids

    Involved Pathway

    MYB involved in several pathways and played different roles in them. We selected most pathways MYB participated on our site, such as C-MYB transcription factor network,Factors involved in megakaryocyte development and platelet production,HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    C-MYB transcription factor network CREBBP,GATA1,TRIM28,ADA,SKI,MYF6,YEATS4,CDKN1B,ADORA2B,CBX4
    Notch-mediated HES/HEY network CTBP1,GATA1,HEY1,BGLAP,MYOD1,RCAN1,GATA6,TLE1,HES6,ASCL1
    IL4-mediated signaling events MYBL1,IgG3,PARP14,EGR2,TFF3,IRF4,RETNLB,DOK2,NIPAL1,CCL26
    HTLV-I infection FZD10,APC,APC2,CCND3,HLA-DQB1,NFKBIA,CANX,ATM,NRP1,HLA-DPA1
    Hemostasis LRRC16A,MMRN2A,RHOGA,SRGN,TRPC6A,PLEK,MAFGA,TREM1,NADL1.1,SLC7A6
    Factors involved in megakaryocyte development and platelet production KIF3A,ZFPM1,KIF3B,CBX5,GATA1A,KIF2A,IRF2,SH2B3,KIFAP3,MAFGB
    Neural Crest Differentiation PRTG,DLL3,HEY2,OLIG1,SOX10,MBP,PMP22,ASCL1,TBX6,PHOX2B

    Protein Function

    MYB has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,WD40-repeat domain binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYB itself. We selected most functions MYB had, and list some proteins which have the same functions with MYB. You can find most of the proteins on our site.

    Function Related Protein
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISL1,FOSB,TP53,MEOX2,SREBF1,FOXJ2,FOSL1,FUBP3,CAMTA1,NR1H2
    protein binding SLC22A3,GABARAPL1,ANKS4B,NEDD4,SETD7,FUBP1,PIF1,UBE2U,ZNF703,PLK3
    WD40-repeat domain binding CDC5L,USP47
    RNA polymerase II core promoter proximal region sequence-specific DNA binding KLF17,MESP1,ZNF713,SP1,HHEX,RFX1A,PHOX2B,ALS2CR8,PGR,LEF1

    Interacting Protein

    MYB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYB here. Most of them are supplied by our site. Hope this information will be useful for your research of MYB.

    SUMO2;SUMO1;ERC2;CLTC;KIF2A;PCDH17;SETD1A;NCAM2;ZFC3H1;NCOR1;PTMS

    Resources

    Research Area

    Transcription Factors in the Akt Pathway
    Hematopoietic Stem Cell Markers
    Epithelial Stem Cell Transcription Factors
    Hematopoietic Stem Cell Transcription Factors and Regulators
    Oncoprotein-Transcription Factors

    References

    • Wang, Z; Fan, C; et al. S5a binds to death receptor-6 to induce THP-1 monocytes to differentiate through the activation of the NF-kappa B pathway. JOURNAL OF CELL SCIENCE 127:3257-3268(2014).
    • Afroze, T; Yang, G; et al. Calcium Efflux Activity of Plasma Membrane Ca2+ ATPase-4 (PMCA4) Mediates Cell Cycle Progression in Vascular Smooth Muscle Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 289:7221-7231(2014).

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