MXD3
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Official Full Name
MAX dimerization protein 3 -
Overview
This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators.;The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters;of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled;cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been;described. -
Synonyms
MXD3;MAX dimerization protein 3;bHLHc13;MAD3;FLJ35523;Likely ortholog of mouse Max dimerization protein 3;MGC2383;MYX;OTTHUMP00000223596;OTTHUMP00000223598;max dimerizer 3;Max-associated protein 3;class C basic helix-loop-helix protein 13;Max-interacting transcriptional repressor MAD3
Recombinant Proteins
- Mouse
- Zebrafish
- Rat
- Human
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
MXD3 involved in several pathways and played different roles in them. We selected most pathways MXD3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MXD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MXD3 has several biochemical functions, for example, DNA binding,protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MXD3 itself. We selected most functions MXD3 had, and list some proteins which have the same functions with MXD3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | HINFP,HMGB1B,ZSCAN4F,CHTF18,THAP3,ZNF167,SP140L,ZNF317,NR4A3,HMGA1A |
| protein dimerization activity | SIM1,SREBF2,ASCL1B,PEX3,PIP4K2AA,MSC,NUP210,HER9,HER5,FERD3L |
| protein binding | NFYA,NR4A3,THAP3,SBDS,MYBPHL,MYL2,ARGLU1,RNF216,UCHL1,SRGAP3 |
Interacting Protein
MXD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MXD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MXD3.
KRTAP10-7;NOTCH2NL;MAGEA11
Resources
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References
- Satake, N; Duong, C; et al. Novel Targeted Therapy for Precursor B Cell Acute Lymphoblastic Leukemia: Anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugates. BLOOD 124:-(2014).
- Satake, N; Duong, C; et al. Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia. BRITISH JOURNAL OF HAEMATOLOGY 167:487-499(2014).
