MX2
-
Official Full Name
myxovirus (influenza virus) resistance 2 (mouse) -
Overview
The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. -
Synonyms
MX2;myxovirus (influenza virus) resistance 2 (mouse);myxovirus (influenza) resistance 2, homolog of murine;interferon-induced GTP-binding protein Mx2;interferon regulated resistance GTP binding protein MXB;MXB;second interferon induced protein p78;Interferon induced GTP binding protein Mx2;Interferon-regulated resistance GTP-binding protein MxB;MX 2;MX2_HUMAN;Myxovirus (influenza virus) resistance 2;Myxovirus resistance 2;Myxovirus resistance protein 2;p78 related protein;p78-related protein;second interferon-induced protein p78
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- GST
Involved Pathway
MX2 involved in several pathways and played different roles in them. We selected most pathways MX2 participated on our site, such as Antiviral mechanism by IFN-stimulated genes,Cytokine Signaling in Immune system,ISG15 antiviral mechanism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ISG15 antiviral mechanism | KPNA5,ARIH1L,EIF4E3,EIF4G2A,EIF4G2,IFIT12,IFIT8,USP18,KPNA4,HERC5 |
| Immune System | CYBA,POLR3F,PELI3,KLHL20,B2ML,PJA1,FCN1,KIF5B,FCGR1B,CTLA4 |
| Cytokine Signaling in Immune system | NEFLB,CNKSR1,GHRB,TRIM6,IRF2,GBP2,TRIM45,WDR83,UBE2V1,HAVCR2 |
| Interferon Signaling | ARIH1,TRIM5,TRIM45,TRIM62,IFIT10,TRIM14,IFI35,IRF9,IFIT14,GBP6 |
| Interferon alpha/beta signaling | BST2,IRF9,IFIT2,IFIT3,OASL,IFI35,SAMHD1,IFITM2,IRF4,IFI27 |
| Antiviral mechanism by IFN-stimulated genes | UBE2L6,EIF4E,NUPL2,IFIT14,NUP35,HERC5,EIF4A2,KPNA3,EIF4A1,EIF4E3 |
Protein Function
MX2 has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MX2 itself. We selected most functions MX2 had, and list some proteins which have the same functions with MX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FBXW9,LRR1,SLC6A4,TAX1BP3,BLK,CUL3,DLG3,NUDT14,PXMP2,PPP4R2 |
| GTP binding | RASEF,TUBB5,ARF5,EEF1A1L2,SEPT9B,IFT22,TUBA8L2,RAB39BB,EEFSEC,RAP1A |
| GTPase activity | RND3,GNA15.4,RRAGA,TUBA1L2,RAB36,ARF1,RRAS2,GNA11,RAB42A,DNM1L |
Interacting Protein
MX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MX2.
EHMT2;PIAS2;ATRIP
Resources
Related Services
Related Products
References
- Burgi, MD; Prieto, C; et al. WISH cell line: From the antiviral system to a novel reporter gene assay to test the potency of human IFN-alpha and IFN-beta. JOURNAL OF IMMUNOLOGICAL METHODS 381:70-74(2012).
- van Baarsen, LGM; Wijbrandts, CA; et al. Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment. ARTHRITIS RESEARCH & THERAPY 12:-(2010).
