MX1
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Official Full Name
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) -
Overview
In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
MX1;myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse);myxovirus (influenza) resistance 1, homolog of murine (interferon inducible protein p78);interferon-induced GTP-binding protein Mx1;IFI 78K;MxA;N-terminally processed;Human interferon regulated resistance GTP binding protein MXA;IFI 78;IFI-78K;IFI78;IFI78K;Interferon induced GTP binding protein Mx1;Interferon induced protein p78;Interferon inducible protein p78;Interferon regulated resistance GTP binding protein;Interferon regulated resistance GTP binding protein MxA;Interferon-induced protein p78;Interferon-regulated resistance GTP-binding protein MxA;MX 1;MX;MX1_HUMAN;Myxoma resistance protein 1;Myxovirus (influenza virus) resistance 1 interferon inducible;Myxovirus (influenza virus) resistance 1 interferon inducible protein p78;Myxovirus (influenza) resistance 1 homolog of murine;Myxovirus resistance protein 1
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Chicken
- Cynomolgus
- Rat
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- Human Cells
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- His&GST
- His&T7
- Myc&DDK
- GST
- Flag
Involved Pathway
MX1 involved in several pathways and played different roles in them. We selected most pathways MX1 participated on our site, such as Measles,Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with MX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Influenza A | HLA-DQB1,IL33,CXCL8,NXT2,ICAM1,IFNGR2,RNASEL,PIK3CD,MAPK12,AKT2 |
| Measles | STAT3,CD3E; CD3D,MAVS,Fasl,SLAMF1,IFNA17,EIF3H,CD3E,PIK3CB,OAS3 |
Protein Function
MX1 has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MX1 itself. We selected most functions MX1 had, and list some proteins which have the same functions with MX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | GNA11,RAB4A,RHOBTB2,RHOGB,ARL3,ARL8B,ARL8BA,EEF2A.2,EIF2B2,RHOJ |
| GTPase activity | RAB19,TUBA1A,RAB7L1,TUBA3D,RABL2A,GNG10,GNL1,LRRK2,RAB35,SRPR |
| protein binding | MRTO4,ZRSR2,PIK3R2,MEPE,DNAJA3,NOL9,PCGF1,HADHB,YOD1,CAML |
Interacting Protein
MX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MX1.
TRPC6;SIAH1;CAB39L;TRPC3;TRPC4;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;TRPC1;TRPC7
Resources
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References
- Riegger, D; Hai, R; et al. The Nucleoprotein of Newly Emerged H7N9 Influenza A Virus Harbors a Unique Motif Conferring Resistance to Antiviral Human MxA. JOURNAL OF VIROLOGY 89:2241-2252(2015).
- Feng, XB; Huang, J; et al. Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus. CLINICAL RHEUMATOLOGY 34:71-79(2015).
