MUM1
-
Official Full Name
melanoma associated antigen (mutated) 1 -
Overview
The MUM1 (Multiple Myeloma Oncogene 1) gene was originally identified because of its involvement in the t(6;14) translocation observed in multiple myeloma, which causes juxtaposition of the MUM1 gene to the lg heavy-chain locus. MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid and extra-hematopoitic tumors. MUM1 is a valuable marker for understanding and characterizing histogenensis of B-cell lymphomas. It is an excellent marker for Hodgkin's and Reed-Sternberg cells of classic Hodgkin's disease in combination with CD30. -
Synonyms
MUM1;melanoma associated antigen (mutated) 1;PWWP domain-containing protein MUM1;MUM 1;protein expandere;melanoma ubiquitous mutated protein;mutated melanoma-associated antigen 1;MUM-1;EXPAND1;HSPC211;FLJ14868;FLJ22283;MGC131891;MGC163315
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi&Fc&His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MUM1-1112H | Recombinant Human MUM1, GST-tagged | E.coli | Human | GST | 1-152aa | |
| MUM1-3191H | Recombinant Human MUM1 protein, His-tagged | E.coli | Human | His | 1-152 aa | |
| MUM1-10238M | Recombinant Mouse MUM1 Protein | Mammalian Cells | Mouse | His |
|
|
| MUM1-5444C | Recombinant Chicken MUM1 | Mammalian Cells | Chicken | His |
|
|
| MUM1-1156HCL | Recombinant Human MUM1 cell lysate | Human | Non |
|
||
| MUM1-5807M | Recombinant Mouse MUM1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
|
|
| MUM1-5807M-B | Recombinant Mouse MUM1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
MUM1 involved in several pathways and played different roles in them. We selected most pathways MUM1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MUM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MUM1 has several biochemical functions, for example, nucleosome binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MUM1 itself. We selected most functions MUM1 had, and list some proteins which have the same functions with MUM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleosome binding | RNF168,RNF169,HP1BP3,RNF4,SMARCA5,ZNHIT1,L3MBTL1,DNTTIP1,ARID1A,NOC2L |
| protein binding | DEPDC1,DOK6,BBS2,DCAF7,DPYSL3,TNFRSF6B,CCDC137,ANKRD54,DHX32,CALCR |
Interacting Protein
MUM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MUM1.
SMC6
Resources
Related Services
Related Products
References
- Treetipsatit, J; Rimzsa, L; et al. Variable Expression of B-cell Transcription Factors in Reactive Immunoblastic Proliferations A Potential Mimic of Classical Hodgkin Lymphoma. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 38:1655-1663(2014).
- Guo, Y; Takeuchi, I; et al. Array-comparative genomic hybridization profiling of immunohistochemical subgroups of diffuse large B-cell lymphoma shows distinct genomic alterations. CANCER SCIENCE 105:481-489(2014).
