MUL1
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Official Full Name
mitochondrial E3 ubiquitin protein ligase 1 -
Overview
A chromosome is an organized structure of DNA and protein found in cells. It is a single piece of coiled DNA containing many genes, regulatory elements and other nucleotide sequences. Chromosomes also contain DNA-bound proteins, which serve to package the DNA and control its functions. -
Synonyms
MUL1;mitochondrial E3 ubiquitin protein ligase 1;C1orf166, chromosome 1 open reading frame 166;mitochondrial ubiquitin ligase activator of NFKB 1;FLJ12875;GIDE;growth inhibition and death E3 ligase;MAPL;mitochondria anchored protein ligase;MULAN;ring finger protein 218;RNF218;0610009K11Rik;AV000801;RGD1309944;RP11-401M16.2;C1orf166;E3 ubiquitin ligase;E3 ubiquitin protein ligase MUL1;Mitochondrial anchored protein ligase;Putative NF kappa B activating protein 266;RP23-25C1.10-002;E3 ubiquitin-protein ligase MUL1;mitochondrial E3 ubiquitin ligase 1;mitochondria-anchored protein ligase;mitochondrial-anchored protein ligase;putative NF-kappa-B-activating protein 266;mitochondrial ubiquitin ligase activator of NF-kB
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Cynomolgus
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
MUL1 involved in several pathways and played different roles in them. We selected most pathways MUL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MUL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MUL1 has several biochemical functions, for example, SUMO transferase activity,identical protein binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MUL1 itself. We selected most functions MUL1 had, and list some proteins which have the same functions with MUL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | RNF144AA,MARCH4,UBE3A,TMEM129,RNF115,MDM2,SIAH2L,RNF20,RNF114,KCMF1 |
| signal transducer activity | CHRM2A,HMOX1,VALOPB,TAS2R106,MAGI2,DRD1B,CBLB,GNA14,GPR34A,GMFB |
| zinc ion binding | WT1,TRIM7,CAHZ,ADAM33,RNF2,MT3,TRAIP,ABLIM2,TRIM48,ADAM23 |
| ubiquitin protein ligase binding | SMAD7,SMAD2,AMBRA1,MC1R,MOAP1,NDUFS2,C10orf46,BAG4,CCT2,TRP53 |
| identical protein binding | APAF1,USP15,USP4,KCTD13,SNX1,CEP72,PIP4K2C,CLDN2,UGP2,MAP1S |
| protein binding | ZNF750,NFE2L3,MITF,GNAI3,TRIM10,ZC3H15,RACGAP1,VEGFB,ODF1,CHN1 |
| ubiquitin-protein transferase activity | RNF20,RCHY1,TRIM32,TRIM13,TRIM5,FBXL3,MGRN1,CBLB,TRIM71,UBE2D2 |
| SUMO transferase activity | SUMO1,UBE2IA,UBE2IB,TOPORS,NSMCE2,CBX4,PIAS3,PIAS4,SUMO4,SUMO3 |
Interacting Protein
MUL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MUL1.
APPBP2;TRIM9;UBE2I;TANK;UBE2L6;UBE2D1;UBE2E1;UBE2D3;UBE2D2;TAP1;UBE2U;UBE2E3;UBE2W;UBE2D4;UBC
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References
- Palus, S; von Haehling, S; et al. Muscle wasting: an overview of recent developments in basic research. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE 5:193-198(2014).
- Belghit, I; Skiba-Cassy, S; et al. Dietary methionine availability affects the main factors involved in muscle protein turnover in rainbow trout (Oncorhynchus mykiss). BRITISH JOURNAL OF NUTRITION 112:493-503(2014).
