MUC5B
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Official Full Name
mucin 5B, oligomeric mucus/gel-forming -
Overview
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. -
Synonyms
MUC5B;mucin 5B, oligomeric mucus/gel-forming;MUC5, mucin 5, subtype B, tracheobronchial;mucin-5B;MG1;tracheobronchial;Cervical mucin;Cervical mucin MUC5B;High molecular weight salivary mucin MG1;MUC-5B;MUC5;MUC5B_HUMAN;MUC9;Mucin 5 subtype B, tracheobronchial;Mucin 5B;Mucin 5B oligomeric mucus/gel forming;Mucin-5 subtype B;Sublingual gland mucin;OTTHUMP00000233052;mucin-5 subtype B, tracheobronchial;mucin 5, subtype B, tracheobronchial
Recombinant Proteins
- Human
- Cattle
- Mouse
- Rat
- Wheat Germ
- E.coli
- GST
- His
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MUC5B-1030H | Recombinant Human MUC5B, GST-tagged | Wheat Germ | Human | GST |
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| MUC5B-783C | Recombinant Cattle MUC5B protein, His-tagged | E.coli | Cattle | His | Gln6489~Tyr6632 |
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| MUC5B-784H | Recombinant Human MUC5B protein, His-tagged | E.coli | Human | His | Lys5366~Val5444 |
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| Muc5b-785M | Recombinant Mouse Muc5b protein, His-tagged | E.coli | Mouse | His | Ala75~Leu295 |
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| Muc5b-786R | Recombinant Rat Muc5b protein, His & GST-tagged | E.coli | Rat | GST&His | Arg3513~Gly3611 |
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| Muc5b-787R | Recombinant Rat Muc5b protein, His & GST-tagged | E.coli | Rat | GST&His | Lys3667~Leu3771 |
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| Muc5b-788R | Recombinant Rat Muc5b protein, His & GST-tagged | E.coli | Rat | GST&His | Ala898~Ile1002 |
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| MUC5B-2465H | Recombinant Human MUC5B Protein, His-tagged | E.coli | Human | His | Cys5653-Val5762 |
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| MUC5B-4400H | Recombinant Human MUC5B protein, His&Myc-tagged | E.coli | Human | His&Myc | 4186-4295aa |
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| MUC5B-5149H | Recombinant Human MUC5B Protein (Ser5657-Ala5756), N-GST tagged | E.coli | Human | GST | Ser5657-Ala5756 |
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Involved Pathway
MUC5B involved in several pathways and played different roles in them. We selected most pathways MUC5B participated on our site, such as Salivary secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUC5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Salivary secretion | ATP1B2,ITPR1,PRKACA,PRKCG,FXYD2,ATP1A1,ATP1B4,MUC7,BEST2,CST1 |
Protein Function
MUC5B has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MUC5B itself. We selected most functions MUC5B had, and list some proteins which have the same functions with MUC5B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | OSTF1,DPYSL4,CD40,CCR3,GNB1,CD163,RHOH,KIR2DL3,FBXO45,CACFD1 |
Interacting Protein
MUC5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUC5B here. Most of them are supplied by our site. Hope this information will be useful for your research of MUC5B.
Resources
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References
- Yunus, MHM; Siang, KC; et al. The effects of human serum to the morphology, proliferation and gene expression level of the respiratory epithelium in vitro. TISSUE & CELL 46:233-240(2014).
- Henderson, AG; Ehre, C; et al. Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure. JOURNAL OF CLINICAL INVESTIGATION 124:3047-3060(2014).
