MUC4
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Official Full Name
mucin 4, cell surface associated -
Overview
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008] -
Synonyms
MUC4;mucin 4, cell surface associated;ASGP;MUC-4;HSA276359;mucin-4;testis mucin;tracheobronchial mucin;ascites sialoglycoprotein;mucin 4, tracheobronchial;pancreatic adenocarcinoma mucin
Recombinant Proteins
- Human
- Rat
- Mouse
- Wheat Germ
- E.coli
- Insect Cells
- Non
- His
- GST
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MUC4-112H | Recombinant Human MUC4 protein, GST-tagged | Wheat Germ | Human | Non | 79-188 a.a. |
|
| MUC4-5763H | Recombinant Human MUC4 protein, His-tagged | E.coli | Human | His | Pro1154~Glu1309 |
|
| MUC4-0215H | Recombinant Human MUC4 Protein (Gly1869-Asn1925), C-His-tagged | Insect Cells | Human | His | Gly1869-Asn1925 |
|
| Muc4-1805R | Recombinant Rat Muc4 Protein, His-tagged | E.coli | Rat | His | Pro1141-Pro1316 |
|
| MUC4-4627H | Recombinant Human MUC4 Protein (Glu1875-Phe1914), N-GST tagged | E.coli | Human | GST | Glu1875-Phe1914 |
|
| MUC4-4628H | Recombinant Human MUC4 Protein (Val2078-Glu2117), N-GST tagged | E.coli | Human | GST | Val2078-Glu2117 |
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| Muc4-5732M | Recombinant Mouse Muc4 protein, His&Myc-tagged | E.coli | Mouse | His&Myc | 2712-2946a.a. |
|
| MUC4-5750H | Recombinant Human MUC4 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| RFL1262RF | Recombinant Full Length Rat Mucin-4(Muc4) Protein, His-Tagged | E.coli | Rat | His | Full L. Full Length of Mature Protein (1616-2344) |
|
Involved Pathway
MUC4 involved in several pathways and played different roles in them. We selected most pathways MUC4 participated on our site, such as Metabolism of proteins,O-linked glycosylation,O-linked glycosylation of mucins, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| O-linked glycosylation of mucins | GALNT13,B3GNT8,MUC1,MUC5AC,GALNT5,B3GNT6,MUC13,MUC15,GALNTL5,MUC20 |
| Termination of O-glycan biosynthesis | MUC12,MUC21,MUC13,MUC20,MUCL1,MUC1,MUC5AC,MUC15 |
| Post-translational protein modification | ADAMTS1,MAGT1,THSD7A,SLC35A1,NSMCE1,B3GNT8,TMED10,PPP6C,ST6GALNAC1.2,ARSH |
| O-linked glycosylation | GALNT5,B3GNT6,SPON2,ADAMTS1,C8orf84,MUC1,THSD7A,B3GALTL,B3GNT8,ADAMTSL5 |
| Metabolism of proteins | CNIH2,ST8SIA2,SEC61B,TIMM50,MUC21,TIMM13,SERPINA7,SENP1,ST6GALNAC1.2,PFDN2 |
Protein Function
MUC4 has several biochemical functions, for example, ErbB-2 class receptor binding,extracellular matrix constituent, lubricant activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MUC4 itself. We selected most functions MUC4 had, and list some proteins which have the same functions with MUC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular matrix constituent, lubricant activity | STATH |
| ErbB-2 class receptor binding | CDK5,NRG1 |
Interacting Protein
MUC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MUC4.
eutG
Resources
Research Area
Epithelial Cell Markers and Intracellular MoleculesApical Molecules
Pancreatic Cancer Biomarkers
Related Services
Related Products
References
- Decouvelaere, AV; et al. Immunohistochemistry in the diagnosis of sarcomas. ANNALES DE PATHOLOGIE 35:98-106(2015).
- Elster, N; Collins, DM; et al. HER2-family signalling mechanisms, clinical implications and targeting in breast cancer. BREAST CANCER RESEARCH AND TREATMENT 149:5-15(2015).
