MTR
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Official Full Name
5-methyltetrahydrofolate-homocysteine methyltransferase -
Overview
MTR encodes the enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. [provided by RefSeq, Jul 2008] -
Synonyms
MTR;5-methyltetrahydrofolate-homocysteine methyltransferase;MS;HMAG;cblG;methionine synthase;cobalamin-dependent methionine synthase;vitamin-B12 dependent methionine synthase;5-methyltetrahydrofolate-homocysteine methyltransferase 1
Recombinant Proteins
- Human
- Chicken
- Rat
- Zebrafish
- Medicago tribuloides
- Mouse
- Mycobacterium Tuberculosis
- E.coli
- Mammalian Cells
- Yeast
- HEK293
- Wheat Germ
- His
- His&Myc
- His&Myc&SUMO
- GST
- His&Fc&Avi
- His&SUMO
- N-His&C-Myc
- N-His-SUMO
Involved Pathway
MTR involved in several pathways and played different roles in them. We selected most pathways MTR participated on our site, such as Cysteine and methionine metabolism,Selenocompound metabolism,One carbon pool by folate, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biosynthesis of amino acids | TKTL1,PFKMB,ALDOC,ENO1B,PAH,ASL,PGK2,BCAT1,MAT2B,PHGDH |
| Cysteine and methionine metabolism | CDO1,GOT2,MPST,LDHBB,CBSA,GOT1,APIP,DNMT3AB,DNMT3A,DNMT4 |
| Selenocompound metabolism | CCBL1,TXNRD1,SEPHS2,MARS2,SPS2,SEPHS1,PAPSS2A,MARS,PAPSS2B,TXNRD3 |
| Metabolic pathways | IDUA,ADI1,ACSL1A,PDHA2,CYP2P7,HK3,IDI1,ADKA,PET112L,ENO3 |
| One carbon pool by folate | ALDH1L1,MTHFD1B,MTHFD2,GART,ATIC,MTFMT,FTCD,MTHFS,AMT,SHMT1 |
Protein Function
MTR has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MTR itself. We selected most functions MTR had, and list some proteins which have the same functions with MTR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
MTR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTR here. Most of them are supplied by our site. Hope this information will be useful for your research of MTR.
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References
- Colombo, GL; Castagna, A; et al. Cost analysis of initial highly active antiretroviral therapy regimens for managing human immunodeficiency virus-infected patients according to clinical practice in a hospital setting. THERAPEUTICS AND CLINICAL RISK MANAGEMENT 10:9-15(2014).
- Gueant, JL; Caillerez-Fofou, M; et al. Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase. BIOCHIMIE 95:1033-1040(2013).
