MTMR2

  • Official Full Name

    myotubularin related protein 2

  • Overview

    This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene.

  • Synonyms

    MTMR2;myotubularin related protein 2;CMT4B;myotubularin-related protein 2;KIAA1073;CMT4B1;MTMR2_HUMAN;OTTHUMP00000204445;OTTHUMP00000204446;OTTHUMP00000204447;OTTHUMP00000204448

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Chicken
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
MTMR2-1090H Recombinant Human MTMR2, GST-tagged E.coli Human GST 294-643aa
MTMR2-3953H Recombinant Human MTMR2 protein, His-tagged E.coli Human His 294-643 aa
MTMR2-2902R Recombinant Rhesus monkey MTMR2 Protein, His-tagged Mammalian Cells Rhesus macaque His
MTMR2-3338C Recombinant Chicken MTMR2 Mammalian Cells Chicken His
MTMR2-8948Z Recombinant Zebrafish MTMR2 Mammalian Cells Zebrafish His
MTMR2-4074HCL Recombinant Human MTMR2 293 Cell Lysate HEK293 Human Non
MTMR2-4075HCL Recombinant Human MTMR2 293 Cell Lysate HEK293 Human Non
MTMR2-2722R Recombinant Rhesus Macaque MTMR2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
MTMR2-2722R-B Recombinant Rhesus Macaque MTMR2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Mtmr2-4217M Recombinant Mouse Mtmr2 Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK
MTMR2-5718H Recombinant Human MTMR2 Protein, GST-tagged Wheat Germ Human GST
MTMR2-6539HF Recombinant Full Length Human MTMR2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 571 amino acids
MTMR2-6712H Recombinant Human MTMR2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK

    Involved Pathway

    MTMR2 involved in several pathways and played different roles in them. We selected most pathways MTMR2 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTMR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inositol phosphate metabolism IPPK,NUDT3,INPP5D,PLCZ1,PIK3CD,TPI1A,PLCD3A,PLCG2,IPMK,TPI1
    Metabolic pathways B3GNT5B,ST3GAL3B,APIP,CYP2C45,INPP5J,BCAT2,COX5B2,HADHB,MGAT1A,NSDHL
    Phosphatidylinositol signaling system PI4K2B,PIK3C2G,CALM2B,DGKZ,SYNJ2,MTMR1B,PIK3R3,PLCD1A,PIK3R3A,TMEM55A

    Protein Function

    MTMR2 has several biochemical functions, for example, phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity,phosphatidylinositol-3-phosphatase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTMR2 itself. We selected most functions MTMR2 had, and list some proteins which have the same functions with MTMR2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PDE6D,GTPBP10,YIPF3,UNC119,ARAP3,SOSTDC1B,CENPK,LEO1,KAZN,DDX21
    protein tyrosine/serine/threonine phosphatase activity SSH3,DUSP11,DUSP13A,PTENA,PTENB,SSH2B,SACM1LA,CTDSPL2B,NT5DC3,EYA3
    phosphatidylinositol-3-phosphatase activity MTMR8,SACM1L,MTMR3,PTEN,MTMR1,MTMR14,MTMR1B,FIG4,MTMR1A,MTM1
    protein tyrosine phosphatase activity PTPRM,DUSP23A,PTPN23A,MTMR7B,PTPRR,PTP4A1,DUSP23,DUSP21,PTPRJ,UBASH3B
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity SACM1LA,MTMR8,CTDSPL2B,NT5DC3,MTMR3,SGPP2,CTDSPL2A,MTMR1B,PTPRQ,MTMR1
    protein homodimerization activity MZF1,TSC2,ATIC,CTBP2,RNF40,CBX1,STK25,BAXB,E2F8,FGFR1

    Interacting Protein

    MTMR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTMR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTMR2.

    NEFL;MTMR12;q7ard3_yerpe;tcaA1;metQ

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