MTA3

  • Official Full Name

    metastasis associated 1 family, member 3

  • Overview

    MTA1, MTA2, and MTA3 and 594 aa (MTA3L) proteins found in both the nucleus and the cytoplasmic compartments. It was identified as an Estrogen receptor (ER) regulated component of the Mi/NuRD histone deacetylase transcriptional repressor. In response to estrogen, MTA3 directly targets Snail, the master regulator of the epithelial to mesenchymal transition (EMT). Regulation of E-cadherin expression due to MTA3 and ER mediated signaling of Snail expression may be an important pathway in human breast tumors. Loss of ER results in decreased MTA3 expression and tamoxifen reduces expression of MTA3 in endometrial cells.

  • Synonyms

    MTA3;metastasis associated 1 family, member 3;metastasis associated gene family, member 3;metastasis-associated protein MTA3;KIAA1266;metastasis associated family, member 3

Recombinant Proteins

  • Human
  • Zebrafish
  • Rhesus macaque
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
MTA3-1072H Recombinant Human MTA3, GST-tagged E.coli Human GST 1-343aa
MTA3-10281Z Recombinant Zebrafish MTA3 Mammalian Cells Zebrafish His
MTA3-2891R Recombinant Rhesus monkey MTA3 Protein, His-tagged Mammalian Cells Rhesus macaque His
MTA3-4092HCL Recombinant Human MTA3 293 Cell Lysate HEK293 Human Non
MTA3-1228H Recombinant Human MTA3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
MTA3-2711R Recombinant Rhesus Macaque MTA3 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
MTA3-2711R-B Recombinant Rhesus Macaque MTA3 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
MTA3-5682H Recombinant Human MTA3 Protein, GST-tagged Wheat Germ Human GST
Mta3-581M Recombinant Mouse Mta3 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
MTA3-6480HF Recombinant Full Length Human MTA3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 515 amino acids

    Involved Pathway

    MTA3 involved in several pathways and played different roles in them. We selected most pathways MTA3 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription BRF1B,CBX3A,SNAPC3,CHD4,GTF3AA,TFB2M,GATAD2B,CBX3,NFIC,ZNF143A
    Chromatin organization SMARCB1,RUVBL2,SETD3,KDM1A,AEBP2,KDM3A,SUZ12,CHD4A,KDM5BB,TADA2A
    RNA Polymerase I Transcription PTRF,MBD3,CHD4A,RRN3,GATAD2B,MBD3A,TAF1A,MTA1,MTA2,CD3EAP
    RNA Polymerase I Transcription Initiation MBD3,GATAD2AB,GATAD2B,CHD4,GATAD2A,CHD4A,RRN3,UBTF,MTA2,MTA1
    HDACs deacetylate histones SAP30,PHF21A,BRMS1,SUDS3,ARID4A,HMG20B,SAP30L,MBD3,MBD3A,SAP18
    Gene Expression MED13B,TAF1D,CSTF3,ZNF230,ZNF544,XPOT,POLR3G,BRF1,NFIB,ZNF485
    Chromatin modifying enzymes MTA2,KDM6AL,HMG20B,SMARCD1,PHF21A,ARID2,JHDM1D,MCRS1,TAF6L,ATF7IP
    RNA Polymerase I Promoter Clearance CD3EAP,MTA1,MBD3,GATAD2B,MBD3A,EFCAB11,EHMT2,GATAD2AB,MTA2,TAF1C

    Protein Function

    MTA3 has several biochemical functions, for example, chromatin binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTA3 itself. We selected most functions MTA3 had, and list some proteins which have the same functions with MTA3. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor activity, sequence-specific DNA binding ZFP14,SCAND3,SOX11B,FOXC1A,ZSCAN2,PRRX2,RFX5,SRF,TGIF1,IRF4A
    chromatin binding MORF4L1,JUB,SKI,PRDM13,ARID3C,PAF1,FOSL2,HMGB3A,PCGF2,KAT2B
    sequence-specific DNA binding PRDM16,FOXK2,FLI1B,ZC3H8,FOXI2,EVE1,NR6A1B,ZSCAN12,NLRP3,SMAD3A
    zinc ion binding GATAD2AB,MKRN3,TRIM35-22,RNF133,RBM14B,MT1E,ZCCHC13,ING3,SETDB1,CAD
    protein binding GLS,RTN4RL1,GSTM4,GRM6,ITGA6,OGG1,BEX5,PER3,SNAI1,KHDC1B

    Interacting Protein

    MTA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTA3.

    HDAC1;HDAC2;MBD3;ESR1;AURKA;BCAR3;BAG4;TGFB1;IGF1R;PARP1

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