MST4
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Official Full Name
serine/threonine protein kinase MST4 -
Overview
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. -
Synonyms
RP6-213H19.1;MASK;serine/threonine-protein kinase MST4;OTTHUMP00000024034;OTTHUMP00000215131;OTTHUMP00000215132;OTTHUMP00000215133;OTTHUMP00000215134;STE20-like kinase MST4;mammalian sterile 20-like 4;Mst3 and SOK1-related kinase;serine/threonine-protein kinase MASK;mammalian Ste20-like protein kinase 4
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- E.coli
- Insect Cells
- Sf9 Cells
- Mammalian Cells
- HEK293
- Sf21 Cells
- GST
- His
- Non
- Avi&Fc&His
Involved Pathway
MST4 involved in several pathways and played different roles in them. We selected most pathways MST4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MST4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MST4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MST4 itself. We selected most functions MST4 had, and list some proteins which have the same functions with MST4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
MST4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MST4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MST4.
STRN3;STRN;MOB4;CTTNBP2NL;SLMAP
Resources
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References
- Jiao, S; Zhang, Z; et al. The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. NATURE IMMUNOLOGY 16:246-U204(2015).
- Madsen, CD; Hooper, S; et al. STRIPAK components determine mode of cancer cell migration and metastasis. NATURE CELL BIOLOGY 17:68-+(2015).
