MSL3
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Official Full Name
male-specific lethal 3 homolog (Drosophila) -
Overview
This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010] -
Synonyms
MSL3;male-specific lethal 3 homolog (Drosophila);MSL3L1;male-specific lethal 3 homolog;MSL3-like 1;male-specific lethal-3 protein-like 1
Recombinant Proteins
- Mouse
- Human
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MSL3-10139M | Recombinant Mouse MSL3 Protein | Mammalian Cells | Mouse | His |
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| MSL3-4112HCL | Recombinant Human MSL3 293 Cell Lysate | HEK293 | Human | Non |
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| MSL3-4113HCL | Recombinant Human MSL3 293 Cell Lysate | HEK293 | Human | Non |
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| Msl3-4190M | Recombinant Mouse Msl3 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| MSL3-5290H | Recombinant Human MSL3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| MSL3-5657H | Recombinant Human MSL3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MSL3-5744M | Recombinant Mouse MSL3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MSL3-5744M-B | Recombinant Mouse MSL3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| MSL3-6460HF | Recombinant Full Length Human MSL3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 521 amino acids |
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Involved Pathway
MSL3 involved in several pathways and played different roles in them. We selected most pathways MSL3 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | ARID5B,ELP2,KDM6AL,HIST2H3C,ZZZ3,MBD3A,MCRS1,KAT5,ANO9A,CAPNS2 |
| HATs acetylate histones | KANSL2,RUVBL2,PHF17,C17orf81,TADA1,ZZZ3,KAT8,TADA3,PHF20B,C3orf75 |
| Chromatin organization | KAT7A,SMYD3,PBRM1,KAT6B,MSL2B,SMARCC2,PHF8,ATXN7L3,ING4,RBBP5 |
Protein Function
MSL3 has several biochemical functions, for example, DNA binding,methylated histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSL3 itself. We selected most functions MSL3 had, and list some proteins which have the same functions with MSL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| methylated histone binding | ATRX,TDRD3,PHF19,ZMYND11,L3MBTL1,PHF1,KDM4A,CBX5,ING5,ING2 |
| DNA binding | TOP3B,HLF,ZFP524,EBF3A,POU6F1,TTF2,ZNF134,STAT5B,OLIG2,ERCC6 |
Interacting Protein
MSL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSL3.
Kat8;CDK6;Map3k1;yitJ;p27958-pro_0000037566;DYRK1B
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