MSH3

  • Official Full Name

    mutS homolog 3
  • Overview

    The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]
  • Synonyms

    MSH3;mutS homolog 3;DUP;MRP1;DNA mismatch repair protein Msh3;hMSH3;mismatch repair protein 1;divergent upstream protein
Cat.# Product name Source (Host) Species Tag Protein Length Price
MSH3-494H Recombinant Human MSH3 Protein, His-tagged E.coli Human His
MSH3-6056Z Recombinant Zebrafish MSH3 Mammalian Cells Zebrafish His
MSH3-23HCL Recombinant Human MSH3 HEK293T cell lysate HEK293 Human DDK&Myc

    Involved Pathway

    MSH3 involved in several pathways and played different roles in them. We selected most pathways MSH3 participated on our site, such as Mismatch repair,Pathways in cancer,Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pathways in cancer LAMC2,FZD6,ARHGEF12,KIT,CTNNA3,FN1,WNT11,PLD1,AGTR1A,TGFBR2
    Colorectal cancer RAC1,BAX,TGFB3,PIK3CB,SMAD4,MAPK8,RAC2,MAPK1,PIK3R3,Casp3
    Mismatch repair RPA2,PMS2,RFC5,MLH3,POLD2,RPA1,PCNA,LIG1,MSH2,RFC2

    Protein Function

    MSH3 has several biochemical functions, for example, ATP binding,DNA-dependent ATPase activity,Y-form DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH3 itself. We selected most functions MSH3 had, and list some proteins which have the same functions with MSH3. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to dinucleotide insertion or deletion binding MSH2
    contributes_to single guanine insertion binding MSH2,MSH6
    heteroduplex DNA loop binding MSH2
    ATP binding DDX20,NTRK2,ASS1,MLKL,EPHB3,IDH3G,ORC4L,SPS2,P2RX5,SLC27A2
    NOT protein homodimerization activity DDIT3,MSH6,MLXIPL,MECOM,MYO9B,NUDT16L1,EXT2,KCNA3
    Y-form DNA binding MEN1,RAD18,WRN,MSH2
    double-strand/single-strand DNA junction binding MSH2
    DNA-dependent ATPase activity SMARCAL1,RAD51B,XRCC3,DMC1,MSH4,SMARCA2,XRCC2,DDX11,ERCC2,RAD51L3
    contributes_to mismatched DNA binding MSH2,MSH6

    Interacting Protein

    MSH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH3.

    PCNA;MLH1;MSH2;RCHY1;ssdna_dn

    Resources

    Research Area

    Tumor Suppressors

    References

    • Muro, Y; Nakashima, R; et al. Autoantibodies to DNA Mismatch Repair Enzymes in Polymyositis/Dermatomyositis and Other Autoimmune Diseases: A Possible Marker of Favorable Prognosis. ARTHRITIS & RHEUMATOLOGY 66:3457-3462(2014).
    • Tome, S; Simard, JP; et al. Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. DNA REPAIR 12:46-52(2013).

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