MSH3
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Official Full Name
mutS homolog 3 -
Overview
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011] -
Synonyms
MSH3;mutS homolog 3;DUP;MRP1;DNA mismatch repair protein Msh3;hMSH3;mismatch repair protein 1;divergent upstream protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MSH3-494H | Recombinant Human MSH3 Protein, His-tagged | E.coli | Human | His | ||
| MSH3-6056Z | Recombinant Zebrafish MSH3 | Mammalian Cells | Zebrafish | His |
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| MSH3-23HCL | Recombinant Human MSH3 HEK293T cell lysate | HEK293 | Human | DDK&Myc |
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Involved Pathway
MSH3 involved in several pathways and played different roles in them. We selected most pathways MSH3 participated on our site, such as Mismatch repair,Pathways in cancer,Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Colorectal cancer | TGFBR2,RAC1,CASP9,RAC2,MSH2,APC2,TGFB3,APPL1,PIK3CD,FOS |
| Mismatch repair | MLH1,LIG1,RFC1,RFC4,PCNA,MSH2,SSBP1,POLD4,RFC5,RPA1 |
| Pathways in cancer | RBX1,STK36,GNG10,VEGFA,CKS2,PTCH2,FZD5,RXRG,CUL2,LAMB2 |
Protein Function
MSH3 has several biochemical functions, for example, ATP binding,DNA-dependent ATPase activity,Y-form DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH3 itself. We selected most functions MSH3 had, and list some proteins which have the same functions with MSH3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to mismatched DNA binding | MSH6,MSH2 |
| protein binding | DUT,POLR3C,CCDC137,MC2R,RNF146,CTSK,ETV7,CCNY,PTPN18,FAM50B |
| double-strand/single-strand DNA junction binding | MSH2 |
| contributes_to single guanine insertion binding | MSH6,MSH2 |
| NOT protein homodimerization activity | MYO9B,MECOM,MLXIPL,EXT2,KCNA3,DDIT3,MSH6,NUDT16L1 |
| centromeric DNA binding | MSH2,CENPC1,KIF2C,CENPB,MLH3,ZW10 |
| Y-form DNA binding | RAD18,WRN,MSH2,MEN1 |
| DNA-dependent ATPase activity | ERCC6,RAD51L3,IGHMBP2,DMC1,SMARCA2,ERCC2,MSH6,MSH5,XRCC3,MSH2 |
| contributes_to single-stranded DNA binding | IGJ,MLH1,POLR2D,MSH2,IGHM,PMS2 |
Interacting Protein
MSH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH3.
PCNA;MLH1;MSH2;RCHY1;ssdna_dn
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References
- Muro, Y; Nakashima, R; et al. Autoantibodies to DNA Mismatch Repair Enzymes in Polymyositis/Dermatomyositis and Other Autoimmune Diseases: A Possible Marker of Favorable Prognosis. ARTHRITIS & RHEUMATOLOGY 66:3457-3462(2014).
- Tome, S; Simard, JP; et al. Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. DNA REPAIR 12:46-52(2013).
