MSC
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Official Full Name
musculin -
Overview
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a;homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in;vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells.;This gene is a downstream target of the B-cell receptor signal transduction pathway. -
Synonyms
MSC;musculin;musculin (activated B cell factor 1);ABF 1;activated B cell factor 1;bHLHa22;activated B-cell factor-1;class A basic helix-loop-helix protein 22;activated B-cell factor 1, homolog of mouse musculin;ABF1;MYOR;ABF-1
Recombinant Proteins
- Mouse
- Human
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- DDK
- Myc
- GST
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MSC-10129M | Recombinant Mouse MSC Protein | Mammalian Cells | Mouse | His |
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| MSC-422HCL | Recombinant Human MSC lysate | HEK293 | Human | Non |
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| MSC-1934H | Recombinant Human MSC Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| Msc-4184M | Recombinant Mouse Msc Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| MSC-5647H | Recombinant Human MSC Protein, GST-tagged | Wheat Germ | Human | GST |
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| MSC-5737M | Recombinant Mouse MSC Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MSC-5737M-B | Recombinant Mouse MSC Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| MSC-6556HF | Recombinant Full Length Human MSC Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 206 amino acids |
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Involved Pathway
MSC involved in several pathways and played different roles in them. We selected most pathways MSC participated on our site, such as Id Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Id Signaling Pathway | TCF12,ACVRL1,MYF6,KDR,TCF3B,ELK3,PAX2,IFI16,MYOG,MYOD1 |
Protein Function
MSC has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding,protein dimerization activity,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MSC itself. We selected most functions MSC had, and list some proteins which have the same functions with MSC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein dimerization activity | NEUROD6B,MYCA,TFE3,LYL1,NPAS4,AHR,EBF3A,MITFB,CLOCKA,POLR2J2 |
| transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding | PROP1,PAX4,BACH2,GZF1,ZBTB16,ARX,BACH1 |
| transcription corepressor activity | ID4,HSBP1,NRIP1,PPP1R13L,CDYL,CITED2,HOMEZB,SKOR2,CBFA2T2,JAZF1 |
| RNA polymerase II distal enhancer sequence-specific DNA binding | CREB1,NR5A2,RUVBL2,CDX2,HNRNPC,REL,POU4F1,NFKB1,H2AFZ,NR1H4 |
| transcription factor activity, sequence-specific DNA binding | ZFP82,GLI4,MESP1,FOXI3A,HNF1B,SLC25A46,POU2F1B,AHR,MAP3K7,ETS2 |
Interacting Protein
MSC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSC here. Most of them are supplied by our site. Hope this information will be useful for your research of MSC.
EWSR1
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References
- Moncaut, N; Cross, JW; et al. Musculin and TCF21 coordinate the maintenance of myogenic regulatory factor expression levels during mouse craniofacial development. DEVELOPMENT 139:958-967(2012).
- Lee, GH; Chang, MY; et al. Essential roles of basic helix-loop-helix transcription factors, Capsulin and Musculin, during craniofacial myogenesis of zebrafish. CELLULAR AND MOLECULAR LIFE SCIENCES 68:4065-4078(2011).
