MRPS22
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Official Full Name
mitochondrial ribosomal protein S22 -
Overview
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. -
Synonyms
MRPS22;mitochondrial ribosomal protein S22;28S ribosomal protein S22, mitochondrial;C3orf5;GIBT;GK002;MRP S22;COXPD5;RPM S22;RPMS22;S22mt;MRP-S22
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MRPS22-10094M | Recombinant Mouse MRPS22 Protein | Mammalian Cells | Mouse | His |
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| MRPS22-5699Z | Recombinant Zebrafish MRPS22 | Mammalian Cells | Zebrafish | His |
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| MRPS22-4144HCL | Recombinant Human MRPS22 293 Cell Lysate | HEK293 | Human | Non |
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| MRPS22-2148H | Recombinant Human MRPS22 Protein (1-360 aa), GST-tagged | E.coli | Human | GST | 1-360 aa |
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| Mrps22-4169M | Recombinant Mouse Mrps22 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| MRPS22-5610H | Recombinant Human MRPS22 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MRPS22-5719M | Recombinant Mouse MRPS22 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MRPS22-5719M-B | Recombinant Mouse MRPS22 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| MRPS22-6484HF | Recombinant Full Length Human MRPS22 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 360 amino acids |
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Involved Pathway
MRPS22 involved in several pathways and played different roles in them. We selected most pathways MRPS22 participated on our site, such as Mitochondrial translation,Mitochondrial translation elongation,Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPS22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial translation | MRPL46,MRRF,MRPL10,MRPL52,MRPL39,MRPL53,MRPL51,MRPL42,MRPS28,TUFM |
| Mitochondrial translation elongation | MRPL44,MRPS33,MRPL42,CHCHD1,MRPL3,MRPL50,MRPL49,MRPL45,MRPS34,MRPS31 |
| Mitochondrial translation initiation | MRPS35,MRPS30,MTFMT,MTIF3,MRPL37,MRPL41,MRPS34,GADD45GIP1,MRPL47,MRPL54 |
| Mitochondrial translation termination | AURKAIP1,MRPL50,MRPL53,MRPL49,MRPL28,MRPS31,GADD45GIP1,MRPS27,MRPS26,ICT1 |
| Organelle biogenesis and maintenance | CLUAP1,B9D1,RABL5,GABPB1,MRPS23,MRPL54,IFT74,BBS1,MKKS,CCDC123 |
Protein Function
MRPS22 has several biochemical functions, for example, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPS22 itself. We selected most functions MRPS22 had, and list some proteins which have the same functions with MRPS22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of ribosome | MRPS18B,RPL29,MRPS6,MRPL51,MRPL10,MRPL37,RPS20,RPS17,MRPS33,RPS18 |
Interacting Protein
MRPS22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPS22 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPS22.
C1qbp;ESR2;Ybx1;NFKBIL1;BTK;SHD;Smad6;MYC;ESR1;TP53;ERBB3;YBX1;ICT1;MAP1LC3A;AGO2;AGO1;SIRT4
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References
- Sotgia, F; Whitaker-Menezes, D; et al. Mitochondria "fuel" breast cancer metabolism Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. CELL CYCLE 11:4390-4401(2012).
