MRPL46
-
Official Full Name
mitochondrial ribosomal protein L46 -
Overview
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. -
Synonyms
MRPL46;mitochondrial ribosomal protein L46;C15orf4, chromosome 15 open reading frame 4;39S ribosomal protein L46, mitochondrial;LIECG2;P2ECSL;mitochondrial;39S ribosomal protein L46;39S ribosomal protein L46 mitochondrial;C15orf4;L46mt;LIECG 2;MGC22762;MRP L46;MRP-L46;MRPL 46;RM46_HUMAN
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
MRPL46 involved in several pathways and played different roles in them. We selected most pathways MRPL46 participated on our site, such as Mitochondrial translation,Mitochondrial translation elongation,Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL46 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial translation termination | MRPL10,MRPS28,MRPL52,MRPL53,MRPL3,GADD45GIP1,MRPL40,MRPL38,MRPL50,MRPS22 |
| Organelle biogenesis and maintenance | RABL5,FBF1,CEP97,MRPS33,MRPL37,MRPL10,MRPL48,TFB1M,CNGA5,GFM1 |
| Mitochondrial translation elongation | GADD45GIP1,MRPL51,MRPL55,MRPL38,MRPL53,MRPL45,MRPL48,MRPS31,CHCHD1,MRPS28 |
| Mitochondrial translation | MRPL44,MRPL41,MRPL10,PTCD3,MRPS36,MRPS28,MRPL38,MTIF3,MRPS34,MRPL52 |
| Mitochondrial translation initiation | ICT1,AURKAIP1,MRPL38,MRPS30,MRPL28,MRPL10,MRPL50,MRPS26,MRPS36,MRPL53 |
Protein Function
MRPL46 has several biochemical functions, for example, hydrolase activity,molecular_function,structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL46 itself. We selected most functions MRPL46 had, and list some proteins which have the same functions with MRPL46. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrolase activity | MPPED2A,PSMC1B,KLK1B16,HE2,STAMBPA,USP9,NPEPPS,PPM1LB,CASPA,Acr |
| structural constituent of ribosome | MRPS14,RPL10,RPS6,RPS3,RPS27.1,RPS21,RPS8,RPS4Y2,MRPS12,RPS9 |
| molecular_function | NDRG3,PRB1,AP1S3,LHFPL2A,SHISA7,FAM169AA,CCDC129,PIGO,C2orf29,TMEM22 |
Interacting Protein
MRPL46 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL46 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL46.
Brwd3;Srp72;C1qbp;SLC25A5;RPL10;HNRNPU;ICT1;Rpl35;MRPL50;MRPL9
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