MRPL2
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Official Full Name
mitochondrial ribosomal protein L2 -
Overview
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. -
Synonyms
MRPL2;mitochondrial ribosomal protein L2;39S ribosomal protein L2, mitochondrial;CGI 22;MRP L14;RPML14;39S ribosomal protein L2, mitochondrial precursor;CGI22;MRPL14;L2mt;MRP-L2;CGI-22;MRP-L14
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His&T7
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MRPL2-987H | Recombinant Human MRPL2, GST-tagged | E.coli | Human | GST | 1-305aa | |
| Mrpl2-1398M | Recombinant Mouse Mrpl2 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Gln34~Asn306 |
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| MRPL2-3766R | Recombinant Rat MRPL2 Protein | Mammalian Cell | Rat | His |
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| MRPL2-681H | Recombinant Human mitochondrial ribosomal protein L2, His-tagged | E.coli | Human | His | 84-202 a.a. |
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| MRPL2-4190HCL | Recombinant Human MRPL2 293 Cell Lysate | HEK293 | Human | Non |
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| MRPL2-3425R | Recombinant Rat MRPL2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| MRPL2-3425R-B | Recombinant Rat MRPL2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| MRPL2-5564H | Recombinant Human MRPL2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MRPL2-6397HF | Recombinant Full Length Human MRPL2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 305 amino acids |
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Involved Pathway
MRPL2 involved in several pathways and played different roles in them. We selected most pathways MRPL2 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome | RPS17,RPL34,RPL13A,RPS8,MRPL23,MRPS2,FAUA,RPL10A,MRPS14,RPL18A |
Protein Function
MRPL2 has several biochemical functions, for example, poly(A) RNA binding,structural constituent of ribosome,transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL2 itself. We selected most functions MRPL2 had, and list some proteins which have the same functions with MRPL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transferase activity | KAT7B,HECTD1,CKBB,CML5,OXCT2A,ELOVL3,ERBB3A,DNMT3AA,PRKG1A,NEK5 |
| structural constituent of ribosome | RPS18,RPL10L,RPS9,RPS20,RPLP2L,MRPS21,RPL17,MRPS31,MRPL9,MRPL35 |
| poly(A) RNA binding | HIST1H1E,ZC3H8,RPN1,DDX56,RPS17,CCAR1,DDX39B,NOSIP,FKBP4,CCDC47 |
Interacting Protein
MRPL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL2.
CMTM4;TRIM63;SMURF2;Brwd3;Ncstn;YBX1;ICT1;EZH2;MRPL50;MASTL;MRPL9;MRPL1
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References
- van der Giezen, M; Birdsey, GM; et al. Fungal hydrogenosomes contain mitochondrial heat-shock proteins. MOLECULAR BIOLOGY AND EVOLUTION 20:1051-1061(2003).
