MRAP
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Official Full Name
melanocortin 2 receptor accessory protein -
Overview
This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. -
Synonyms
MRAP;melanocortin 2 receptor accessory protein;C21orf61, chromosome 21 open reading frame 61;melanocortin-2 receptor accessory protein;B27;FALP;fat tissue-specific low MW protein;fat cell-specific low molecular weight protein;FGD2;GCCD2;C21orf6
Recombinant Proteins
- Mouse
- Human
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Fc
- Non
- Myc&DDK
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MRAP-10009M | Recombinant Mouse MRAP Protein | Mammalian Cells | Mouse | His |
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| MRAP-683H | Recombinant Human MRAP protein(Tyr59-Ser172), hFc-tagged | HEK293 | Human | Fc | Tyr59-Ser172 |
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| MRAP-1131HCL | Recombinant Human MRAP cell lysate | Human | Non |
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| MRAP-1436H | Recombinant Human MRAP Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Mrap-4133M | Recombinant Mouse Mrap Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| MRAP-5530H | Recombinant Human MRAP Protein, GST-tagged | Wheat Germ | Human | GST |
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| MRAP-5662M | Recombinant Mouse MRAP Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MRAP-5662M-B | Recombinant Mouse MRAP Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| MRAP-6341HF | Recombinant Full Length Human MRAP Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 172 amino acids |
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Involved Pathway
MRAP involved in several pathways and played different roles in them. We selected most pathways MRAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MRAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MRAP has several biochemical functions, for example, corticotropin hormone receptor binding,protein binding,type 1 melanocortin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MRAP itself. We selected most functions MRAP had, and list some proteins which have the same functions with MRAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| type 4 melanocortin receptor binding | ASIP,POMC,MRAP2,a |
| type 3 melanocortin receptor binding | MRAP2,POMC,ASIP,a |
| type 1 melanocortin receptor binding | POMC,MRAP2,AGRP2 |
| corticotropin hormone receptor binding | MRAP2 |
| protein binding | DHDDS,SGK3,CCPG1,OGT,ATPAF1,DENND2D,IK,CD80,TCTE3,INPPL1 |
| type 5 melanocortin receptor binding | MRAP2 |
Interacting Protein
MRAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRAP here. Most of them are supplied by our site. Hope this information will be useful for your research of MRAP.
MRAP2;MC4R;MC5R;MC3R;MC1R
Resources
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References
- Johnson, SR; Swinton, JR; et al. Prognostic factors for survival in scleroderma associated pulmonary arterial hypertension. JOURNAL OF RHEUMATOLOGY 35:1584-1590(2008).
- Sebag, JA; Hinkle, PM; et al. Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104:20244-20249(2007).
