MPST
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Official Full Name
mercaptopyruvate sulfurtransferase -
Overview
This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. -
Synonyms
MPST;mercaptopyruvate sulfurtransferase;3-mercaptopyruvate sulfurtransferase;human liver rhodanese;MST;TST2;3 mercaptopyruvate sulfurtransferase;MGC24539;THTM_HUMAN;OTTHUMP00000197786;OTTHUMP00000197787;OTTHUMP00000197788;OTTHUMP00000197789;OTTHUMP00000197791
Recombinant Proteins
- Rhesus macaque
- Human
- Rat
- Chicken
- Mouse
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- Non
- His&T7
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
MPST involved in several pathways and played different roles in them. We selected most pathways MPST participated on our site, such as Cysteine and methionine metabolism,Sulfur metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MPST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sulfur metabolism | cysH,PAPSS2A,SUOX,PAPSS2,CYCS,IMPAD1,CYCSB,SQRDL,TST,BPNT1 |
| Cysteine and methionine metabolism | LDHAL6B,GOT2,LDHB,DNMT3,LDHAL6A,SDS,GSS,BHMT,GCLM,ENOPH1 |
| Metabolic pathways | PRPS1L1,GPIA,B3GALT5,PTGDSB,SORD,HSD3B4,PRDX6,B3GAT3,PAPSS2A,OLAH |
| Sulfur relay system | CTU1,MOCS2,MOCS1,NFS1,URM1,MOCS3,TST,LBH,TRMU,CTU2 |
Protein Function
MPST has several biochemical functions, for example, 3-mercaptopyruvate sulfurtransferase activity,identical protein binding,thiosulfate sulfurtransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MPST itself. We selected most functions MPST had, and list some proteins which have the same functions with MPST. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | CD28,MAPK1IP1,ACPP,UBE4A,PARP1,MICALL1,ESYT2,SMAD6,GCG,NCAM1 |
| thiosulfate sulfurtransferase activity | TST,MOCS3 |
Interacting Protein
MPST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MPST here. Most of them are supplied by our site. Hope this information will be useful for your research of MPST.
CHM;TFAP2A
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References
- Papenbrock, J; Schmidt, A; et al. Characterization of two sulfurtransferase isozymes from Arabidopsis thaliana. EUROPEAN JOURNAL OF BIOCHEMISTRY 267:5571-5579(2000).
- Bauer, M; Dietrich, C; et al. Intracellular localization of Arabidopsis sulfurtransferases. PLANT PHYSIOLOGY 135:916-926(2004).
