MOV10
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Official Full Name
Mov10, Moloney leukemia virus 10, homolog (mouse) -
Overview
MOV10 may be an helicase with an important function in development and/or control of cell proliferation. RNA silencing processes are guided by small RNAs known as siRNAs and microRNAs (miRNAs). They reside in ribonucleoprotein complexes, which guide the cleavage of complementary mRNAs or affect stability and translation of partial complementary mRNAs. Argonaute (Ago) proteins are at the heart of silencing effector complexes and bind the single-stranded siRNA and miRNA. Ago1- and Ago2-containing complexes have been purified from human cells, resulting in the discovery of novel factors such as the putative RNA helicase MOV10, and the RNA recognition motif (RRM)-containing protein TNRC6B/KIAA1093. The new proteins localize, similar to Ago proteins, to mRNA-degrading cytoplasmic P bodies, and they are functionally required to mediate miRNA-guided mRNA cleavage. -
Synonyms
MOV10;Mov10, Moloney leukemia virus 10, homolog (mouse);gb110;fSAP113;putative helicase MOV-10;moloney leukemia virus 10 protein;functional spliceosome-associated protein 113
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
MOV10 involved in several pathways and played different roles in them. We selected most pathways MOV10 participated on our site, such as Adaptive Immune System,Beta-catenin independent WNT signaling,Ca2+ pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MOV10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DAP12 interactions | JAK1,FGF8B,DUSP9,PAQR3A,DUSP7,FGF18B,TREM1,FRS2,CNKSR1,AGO2 |
| Downstream signal transduction | SPTA1,CRKL,FRS3,FGF10B,SPRED1,DAB2IPB,DUSP9,SPTB,IL17RD,CNKSR1 |
| Cellular Senescence | ACD,SUZ12A,RAD50,EED,HIST1H1C,CBX8A,TNIK,HIST1H1D,HIST3H2BB,HTATIP |
| Adaptive Immune System | ASB18,NCR3LG1,ITPR2,SH3RF1,ASB6,LTN1,RNF220,BLMH,GRAP2A,CTSK |
| DAP12 signaling | SPRED2,FGF18B,CSF2RB,PEA15A,JAK3,DUSP6,SPTB,KBTBD7,DUSP1,FGF10B |
| Cellular responses to stress | IGFBP7,HDAC6,HBXIP,HMGA1-RS1,CDKN2C,UBN1,TXN,GABARAP,HIF1AN,HSPA14 |
| Ca2+ pathway | AGO3,AGO2,GNB5,AGO1 |
| Beta-catenin independent WNT signaling | CLTB,ROR2,PRICKLE1B,RYK,AP2B1,AP2S1,DVL2,CLTA,AGO1,CTNNB2 |
Protein Function
MOV10 has several biochemical functions, for example, ATP binding,helicase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MOV10 itself. We selected most functions MOV10 had, and list some proteins which have the same functions with MOV10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | NOC3L,FNDC3B,EDF1,TMSB4X,C1orf131,DIAPH1,CSTF2T,CDK11B,TRMT1L,SF3A1 |
| protein binding | ZBTB9,AVPI1,2610109H07Rik,CMTM3,RNF40,PACSIN1,ZGPAT,FTH1,NHP2L1,CDH2 |
| helicase activity | BAT1,RAD54L,ANXA1,EIF4A1,GTF2F2A,CHD7,CHD6,HELZ,FANCM,MOV10B.2 |
| ATP binding | NAIP7,Abca2,STK31,ACVR1L,ABCG3,SKIV2L,PRKACB,TGFBR1A,STK16,PRKACAA |
Interacting Protein
MOV10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MOV10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MOV10.
YBX1;EIF2AK2;ATG12;PUF60;NS1;CBX4;AIM2;IFIT3;NS;GABARAP;CBX6;NS;US11;IFIT1;Rc3h2;Zfp36;MNDA;HNRNPH2
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References
- Nakano, M; Kakiuchi, Y; et al. MOV10 as a novel telomerase-associated protein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 388:328-332(2009).
- Wulczyn, FG; Smirnova, L; et al. Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB JOURNAL 21:415-426(2007).
